Healing Rate and Time to Closure of Venous Leg Ulcers: A Real-World Service Evaluation of Neuromuscular Electrostimulation as an Adjunct to Compression Therapy.

Objective: To perform a service evaluation of neuromuscular electrostimulation (NMES) as an adjunct to compression therapy, comparing the rate of wound margin advance and time to closure with a matched retrospective control group.

Methods: Fifteen patients with venous leg ulcers were prescribed NMES for 6 hours per day for 56 days or until wound closure (whichever occurred first), in addition to multilayer compression. Wounds were selected for size, with an inclusion criterion of a maximum of 12 cm2. Wound progress was compared with 15 retrospective control patients who were matched for ulcer size and duration.

Results: The retrospective group had a healing rate of 0.31 mm per week (95% CI, 29-37 mm/week), whereas the prospective compression plus NMES group had a healing rate of 0.56 mm per week (95% CI, 50-62 mm/week; P = .004). All wounds in both groups healed completely during the service evaluation. Mean time to closure for the retrospective group was 77 days (95% CI, 66-88 days), whereas the NMES group had a mean time to closure of 40 days (95% CI, 37-43 days; P = .005).

Conclusions: Adding NMES of the common peroneal nerve to a care bundle including multicomponent compression resulted in significantly faster wound margin advance and significantly less time to heal in comparison with retrospective matched controls. Future randomized controlled trials or self-controlled studies of this approach would be of great interest to inform clinical practice.