曲马多与苯二氮卓类药物合用致致命中毒1例

IF 1.3 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine Pub Date : 2025-04-01 DOI:10.1016/j.legalmed.2025.102619

Sella Takei , Hiroshi Kinoshita , Mitsuru Kumihashi , Mostofa Jamal , Tadayoshi Yamashita , Etsuko Tanaka , Sachiko Kawahara , Hiroko Abe , Kunihiko Tsutsui , Takehiko Murase

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引用次数: 0

摘要

曲马多通过μ-阿片受体激动剂和抑制血清素和去甲肾上腺素的再摄取发挥镇痛作用。在这里，我们报告了一名30多岁的女性尸检病例，发现了多种药物。根据尸检结果和毒理学检查结果，我们得出结论，死亡归因于摄入曲马多和苯二氮卓类药物，这被认为主要是由中枢神经系统抑郁引起的。在评估毒性时应考虑共同摄入的药物。

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A case of fatal poisoning caused by a combination of tramadol and benzodiazepines

Tramadol exerts analgesic effects by acting as an agonist of μ-opioid receptor and by inhibiting reuptake of serotonin and noradrenaline. Here we report an autopsy case of a woman in her thirties, with multiple drugs detected. Based on the autopsy findings and toxicological examination results, we concluded the death was attributed to the ingestion of tramadol and benzodiazepines, which was thought to have primarily resulted from CNS depression. Co-ingested drugs should be considered when evaluating toxicity.

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来源期刊

Legal Medicine Nursing-Issues, Ethics and Legal Aspects

CiteScore

2.80

自引率

6.70%

发文量

119

审稿时长

7.9 weeks

期刊介绍： Legal Medicine provides an international forum for the publication of original articles, reviews and correspondence on subjects that cover practical and theoretical areas of interest relating to the wide range of legal medicine. Subjects covered include forensic pathology, toxicology, odontology, anthropology, criminalistics, immunochemistry, hemogenetics and forensic aspects of biological science with emphasis on DNA analysis and molecular biology. Submissions dealing with medicolegal problems such as malpractice, insurance, child abuse or ethics in medical practice are also acceptable.