脑瘫患者肌肉力量和力量的年龄相关轨迹及其与行走能力的关系

IF 2.2 3区医学 Q3 NEUROSCIENCES

Gait & posture Pub Date : 2025-04-03 DOI:10.1016/j.gaitpost.2025.03.028

Mattie E. Pontiff , Noelle G. Moreau

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引用次数: 0

摘要

背景许多脑性瘫痪（CP）患者在衰老过程中都会出现停止行走的情况。肌力和力量与 CP 患者的行走能力有关。然而，与年龄相关的肌力和力量变化轨迹以及它们与典型发育（TD）患者的变化轨迹的比较尚不清楚。此外，确定哪种肌肉表现（力量或功率）与行走能力更密切相关，可指导临床评估肌肉表现，这对 CP 患者的活动能力最有意义。研究问题CP 和 TD 患者的年龄与肌肉表现之间的关联是否存在差异？与肌力相比，CP 患者的肌力是否与行走能力有更密切的关系？研究方法采用线性回归和方差分析法研究了 CP 患者（n = 66，13.5 ± 4.8 岁，GMFCS I-IV）和 TD 患者（n = 42，16.8 ± 6.1 岁）在肌力和肌力方面与年龄相关的差异。结果两组的肌肉力量和功率与年龄之间的线性回归均具有统计学意义。与 CP 相比，TD 的肌力和力量与年龄相关的变化明显更大。归一化肌力和力量与年龄的线性回归在 TD 患者中显著，而在 CP 患者中不显著。所有步行能力的测量结果都与力量和功率有明显的相关性，但肌肉功率的相关性更强（p < 0.05）。在按体重进行归一化处理后，CP 中未观察到与年龄相关的变化，这表明随着年龄的增长，肌力和力量的增加不足以抵消体重的增加。与力量相比，肌肉力量与行走能力的关系更为密切。

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Age-related trajectories of muscle strength and power in individuals with cerebral palsy and the relationship to walking capacity

Background

Cessation of walking is a consequence of aging in many individuals with Cerebral Palsy (CP). Muscle strength and power are associated with walking capacity in those with CP. However, the age-related trajectories in strength and power and how they compare to trajectories of those with typical development (TD) are unknown. Additionally, determining which measure of muscle performance (strength or power) is more closely associated with walk capacity may guide clinical assessments of muscle performance that are most meaningful to mobility in those with CP.

Research question

Do the associations between age and muscle performance differ between individuals with CP and TD? Is muscle power more strongly associated with walking capacity compared to muscle strength in those with CP?

Methods

Age-related differences in muscle strength and power between individuals with CP (n = 66, 13.5 ± 4.8 years, GMFCS I–IV) and TD (n = 42, 16.8 ± 6.1 years) were examined with linear regression and ANCOVA. Associations between measures of walking capacity and strength and power were evaluated with Pearson’s (r).

Results

Linear regression between muscle strength and power with age was statistically significant in both groups. Age-related changes in strength and power were significantly greater in TD compared to CP. Linear regression between normalized strength and power with age was significant in those with TD but not in CP. All measures of walking capacity were significantly associated with both strength and power, but muscle power was more strongly correlated (p < 0.05).

Significance

Although age-related changes were observed in both groups, individuals with TD demonstrated greater age-related changes in muscle power and strength than those with CP. After normalizing by body mass, no age-related changes were observed in CP, suggesting that gains in power and strength are insufficient to offset increases in body mass with age. Muscle power had a stronger relationship to walking capacity than strength.

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来源期刊

Gait & posture 医学-神经科学

CiteScore

4.70

自引率

12.50%

发文量

616

审稿时长

6 months

期刊介绍： Gait & Posture is a vehicle for the publication of up-to-date basic and clinical research on all aspects of locomotion and balance. The topics covered include: Techniques for the measurement of gait and posture, and the standardization of results presentation; Studies of normal and pathological gait; Treatment of gait and postural abnormalities; Biomechanical and theoretical approaches to gait and posture; Mathematical models of joint and muscle mechanics; Neurological and musculoskeletal function in gait and posture; The evolution of upright posture and bipedal locomotion; Adaptations of carrying loads, walking on uneven surfaces, climbing stairs etc; spinal biomechanics only if they are directly related to gait and/or posture and are of general interest to our readers; The effect of aging and development on gait and posture; Psychological and cultural aspects of gait; Patient education.