Yanlin Wang, Fan Rong, Xiaoyi Sun, Duohang Bi, Yin Wang, Yijing Liu and Jintao Zhu
{"title":"微针经皮 H₂S 气体疗法治疗牛皮癣","authors":"Yanlin Wang, Fan Rong, Xiaoyi Sun, Duohang Bi, Yin Wang, Yijing Liu and Jintao Zhu","doi":"10.1039/D4PY01431F","DOIUrl":null,"url":null,"abstract":"<p >Psoriasis is a common chronic skin disease. Current psoriasis treatments face challenges such as low drug bioavailability and side effects. Hydrogen sulfide (H<small><sub>2</sub></small>S) can be a potential therapeutic for psoriasis, while developing an effective delivery system and a controlled release strategy is essential to guarantee its efficacy and safety. We report a responsive microneedle (MN)-mediated transdermal H<small><sub>2</sub></small>S gas therapy for treating psoriasis. The phenylboronic acid-modified hyaluronic acid (HP) and a peptide H<small><sub>2</sub></small>S donor (AlaCOS) are synthesized, which assemble into H<small><sub>2</sub></small>S donating nanoparticles (HP-AC NPs). The HP-AC NPs efficiently release AlaCOS in aqueous solution or acidic conditions, which can further release H<small><sub>2</sub></small>S triggered by aminopeptidase N (APN) and carbonic anhydrase (CA). Moreover, the HP-AC NPs can effectively downregulate the pro-inflammatory cytokines in macrophages. Furthermore, the HP-AC NP-loaded MNs (HP-AC MN) are prepared with sufficient mechanical strength to penetrate the stratum corneum barrier. In the psoriatic mouse model, the mice receiving the HP-AC MN treatment exhibit decreased epidermal thickness, reduced levels of pro-inflammatory cytokines, and induced M2 polarization of macrophages. This MN-mediated H<small><sub>2</sub></small>S gas therapy represents a promising alternative for treating psoriasis.</p>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":" 18","pages":" 2117-2127"},"PeriodicalIF":3.9000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microneedle-mediated transdermal H2S gas therapy for psoriasis†\",\"authors\":\"Yanlin Wang, Fan Rong, Xiaoyi Sun, Duohang Bi, Yin Wang, Yijing Liu and Jintao Zhu\",\"doi\":\"10.1039/D4PY01431F\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Psoriasis is a common chronic skin disease. Current psoriasis treatments face challenges such as low drug bioavailability and side effects. Hydrogen sulfide (H<small><sub>2</sub></small>S) can be a potential therapeutic for psoriasis, while developing an effective delivery system and a controlled release strategy is essential to guarantee its efficacy and safety. We report a responsive microneedle (MN)-mediated transdermal H<small><sub>2</sub></small>S gas therapy for treating psoriasis. The phenylboronic acid-modified hyaluronic acid (HP) and a peptide H<small><sub>2</sub></small>S donor (AlaCOS) are synthesized, which assemble into H<small><sub>2</sub></small>S donating nanoparticles (HP-AC NPs). The HP-AC NPs efficiently release AlaCOS in aqueous solution or acidic conditions, which can further release H<small><sub>2</sub></small>S triggered by aminopeptidase N (APN) and carbonic anhydrase (CA). Moreover, the HP-AC NPs can effectively downregulate the pro-inflammatory cytokines in macrophages. Furthermore, the HP-AC NP-loaded MNs (HP-AC MN) are prepared with sufficient mechanical strength to penetrate the stratum corneum barrier. In the psoriatic mouse model, the mice receiving the HP-AC MN treatment exhibit decreased epidermal thickness, reduced levels of pro-inflammatory cytokines, and induced M2 polarization of macrophages. This MN-mediated H<small><sub>2</sub></small>S gas therapy represents a promising alternative for treating psoriasis.</p>\",\"PeriodicalId\":100,\"journal\":{\"name\":\"Polymer Chemistry\",\"volume\":\" 18\",\"pages\":\" 2117-2127\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/py/d4py01431f\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/py/d4py01431f","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
牛皮癣是一种常见的慢性皮肤病。目前的银屑病治疗面临着药物生物利用度低和副作用等挑战。硫化氢(H₂S)可能是一种潜在的治疗银屑病的药物,而开发有效的给药系统和控释策略对于保证其疗效和安全性至关重要。我们报道了一种反应灵敏的微针(MN)介导的透皮h2s气体疗法治疗牛皮癣。合成了苯基硼酸修饰的透明质酸(HP)和肽H₂S供体(AlaCOS),并将其组装成H₂S供体纳米粒子(HP- ac NPs)。HP-AC NPs在水溶液或酸性条件下均能有效释放AlaCOS,并进一步释放由氨肽酶N (APN)和碳酸酐酶(CA)触发的H₂S。HP-AC NPs可以有效下调巨噬细胞的促炎细胞因子。此外,制备的HP-AC np负载MN (HP-AC MN)具有足够的机械强度穿透角质层屏障。在银屑病小鼠模型中,接受HP-AC MN处理的小鼠表皮厚度降低,促炎细胞因子水平降低,巨噬细胞M2极化诱导。这种mn介导的h2s气体疗法是治疗牛皮癣的一种有希望的替代疗法。
Microneedle-mediated transdermal H2S gas therapy for psoriasis†
Psoriasis is a common chronic skin disease. Current psoriasis treatments face challenges such as low drug bioavailability and side effects. Hydrogen sulfide (H2S) can be a potential therapeutic for psoriasis, while developing an effective delivery system and a controlled release strategy is essential to guarantee its efficacy and safety. We report a responsive microneedle (MN)-mediated transdermal H2S gas therapy for treating psoriasis. The phenylboronic acid-modified hyaluronic acid (HP) and a peptide H2S donor (AlaCOS) are synthesized, which assemble into H2S donating nanoparticles (HP-AC NPs). The HP-AC NPs efficiently release AlaCOS in aqueous solution or acidic conditions, which can further release H2S triggered by aminopeptidase N (APN) and carbonic anhydrase (CA). Moreover, the HP-AC NPs can effectively downregulate the pro-inflammatory cytokines in macrophages. Furthermore, the HP-AC NP-loaded MNs (HP-AC MN) are prepared with sufficient mechanical strength to penetrate the stratum corneum barrier. In the psoriatic mouse model, the mice receiving the HP-AC MN treatment exhibit decreased epidermal thickness, reduced levels of pro-inflammatory cytokines, and induced M2 polarization of macrophages. This MN-mediated H2S gas therapy represents a promising alternative for treating psoriasis.
期刊介绍:
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.