听觉神经密度和同步对老年人工耳蜗使用者言语理解的贡献。

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Kara C Schvartz-Leyzac, Carolyn M McClaskey, James W Dias, Bryan E Pfingst, Kelly C Harris
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引用次数: 0

摘要

目的:大多数成人人工耳蜗(CI)接受者年龄在65岁以上,先前对未植入人工耳蜗的老年人的研究表明,听神经(AN)病理生理导致了老年人语言理解能力的衰退。然而,与年龄相关的AN结构和功能变化尚未被探索为老年CI用户较差的语音理解结果的促成因素。在这里,我们探讨了CI用户的AN脱离(即AN密度)和不同步的估计如何导致老年CI用户观察到的较差的语音识别性能。方法:我们检测了47例成年(男性= 25)脑内灌注受体的电诱发复合动作电位(ECAPs)。我们分别测量了幅生长函数(AGF)斜率和N1-P2峰间潜伏期的间期间隙(IPG)效应,作为AN密度和非同步性的独立指标。结果:老年CI听者的AN密度和非同步性随着年龄的增长而恶化。这些指标之间没有显著的相关性,但在噪声性能上与语音识别独立相关。在老年CI使用者中观察到较低的ECAP IPG效应值(AN纤维密度较低)。在老年CI用户中也观察到较长的N1-P2峰间延迟值(较差的神经同步性)。在控制听者年龄时,较差的AN不同步导致CI用户在噪声中语音识别性能的下降。结论:这些结果表明,AN不同步而不是密度是CI使用者年龄相关的言语理解能力下降的主要因素。这些结果对于更好地理解成人CI使用者对言语理解的神经贡献具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contributions of Auditory Nerve Density and Synchrony to Speech Understanding in Older Cochlear Implant Users.

Purpose: The majority of adult cochlear implant (CI) recipients are over the age of 65, and previous research in non-implanted older adults shows that auditory nerve (AN) pathophysiology contributes to senescent declines in speech understanding. However, age-related changes to AN structure and function have not yet been explored as a contributory factor to poorer speech understanding outcomes in older CI users. Here, we explore how estimates of AN disengagement (i.e., AN density) and dyssynchrony in CI users contribute to poorer speech recognition performance observed in older CI users.

Methods: We examined electrically evoked compound action potentials (ECAPs) in 47 adult (Male = 25) CI recipients. We measured the interphase gap (IPG) effect for the amplitude-growth function (AGF) slope and the N1-P2 interpeak latency as independent metrics of AN density and dyssynchrony, respectively.

Results: Estimates of AN density and dyssynchrony worsen with increasing age in older CI listeners. These measures were not significantly correlated with one another, but were independently related to speech recognition in noise performance. Lower ECAP IPG effect values (lower density of AN fibers) are observed in older CI users. Longer N1-P2 interpeak latency values (poorer neural synchrony) are also observed in older CI users. When controlling for listener age, poorer AN dyssynchrony contributes to declines in speech-recognition-in-noise performance in CI users.

Conclusion: These results suggest that AN dyssynchrony rather than density is the primary contributing factor to age-related declines in speech understanding in CI users. These results have important implications for better understanding neural contributions to speech understanding in adult CI users.

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来源期刊
CiteScore
4.10
自引率
12.50%
发文量
57
审稿时长
6-12 weeks
期刊介绍: JARO is a peer-reviewed journal that publishes research findings from disciplines related to otolaryngology and communications sciences, including hearing, balance, speech and voice. JARO welcomes submissions describing experimental research that investigates the mechanisms underlying problems of basic and/or clinical significance. Authors are encouraged to familiarize themselves with the kinds of papers carried by JARO by looking at past issues. Clinical case studies and pharmaceutical screens are not likely to be considered unless they reveal underlying mechanisms. Methods papers are not encouraged unless they include significant new findings as well. Reviews will be published at the discretion of the editorial board; consult the editor-in-chief before submitting.
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