估计心肺功能轨迹与中风及其亚型之间的关系：一项前瞻性队列研究。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-02-21 DOI:10.1016/j.numecd.2025.103923

Hui Luo , Shuohua Chen , Xue Tian , Zemeng Zhao , Lili Luo , Shouling Wu , Yanxia Luo , Anxin Wang

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引用次数: 0

摘要

背景和目的：估计的心肺适能（eCRF）与脑卒中之间的关联存在种族异质性，不同脑卒中亚型之间的结论也不一致。目的是研究中国人群中eCRF轨迹与脑卒中及其亚型之间的关系。方法和结果：来自开滦研究（2006-2021）的37,881名参与者在2010年之前或期间接受了三波调查，无癌症和中风。主要结局为脑卒中，包括缺血性脑卒中（IS）和脑出血（ICH）。使用Cox比例风险模型评估两者之间的关系。2006-2010年期间确定了三种不同的eCRF轨迹：低、中、高。在中位随访11.04年（四分位数范围：10.65-11.33）期间，共报告了2150例卒中事件，其中包括1944例IS和231例ICH。与低eCRF轨迹组相比，高eCRF轨迹组的参与者卒中风险降低31%（危险比[HR] [95% CI]， 0.69 [0.60-0.81]）， IS风险降低30% (0.70 [0.59-0.82])，ICH风险降低43%（0.57[0.36-0.91]）。值得注意的是，高eCRF轨迹与IS之间的相关性（p - interaction = 0.0270）在女性中强于男性。结论：长期高eCRF水平与卒中风险降低相关，尤其是脑出血风险降低。因此，随着时间的推移，达到或维持较高的eCRF水平可能是降低卒中风险的有益策略。

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Association between estimated cardiorespiratory fitness trajectory and stroke and its subtypes: A prospective cohort study

Background and aims

The association between estimated cardiorespiratory fitness (eCRF) and stroke is ethnically heterogeneous, and conclusions are inconsistent among different stroke subtypes. The aim was to examine the relationship between eCRF trajectory and stroke and its subtypes in the Chinese population.

Methods and results

37,881 participants from the Kailuan Study (2006–2021) who underwent three waves survey and were free of cancer and stroke before or during 2010 were included in this study. The main outcome was stroke, involving ischemic stroke (IS) and intracerebral hemorrhage (ICH). The relationships were assessed using the Cox proportional hazard model. Three distinct eCRF trajectories were identified during 2006–2010: low, moderate, and high. A total of 2150 stroke events, including 1944 cases of IS and 231 cases of ICH, were reported during a median follow-up of 11.04 (interquartile range: 10.65–11.33) years. Compared to the low eCRF trajectory group, participants in the high eCRF trajectory group were associated with a 31 % lower risk of stroke (hazard ratio [HR] [95 % CI], 0.69 [0.60–0.81]), a 30 % lower risk of IS (0.70 [0.59–0.82]), and a 43 % lower risk of ICH (0.57 [0.36–0.91]). Notably, the association between the high eCRF trajectory and IS (P _interaction = 0.0270) was stronger among women than men.

Conclusion

A long-term high eCRF level is associated with a decreased risk of stroke, especially ICH. Therefore, achieving or sustaining a high eCRF level over time could be a beneficial strategy for decreasing the risk of stroke.

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.