Yi Zhou, Yinglong Duan, Jian Zhou, Qinqin Cheng, Ning Qin, Xing Zhou, Yuxuan Li, Juan Luo, Huiyi Zhang, Jiayi Zhu, Jianfei Xie, Andy S K Cheng
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引用次数: 0
摘要
目的：本研究探讨了心理健康、生物标志物和生活质量（QoL）在影响青少年和年轻成人（AYA）癌症患者的茁壮成长（定义为复原力和幸福感的增强）中的作用：共对 148 名青少年和青年癌症患者进行了心理健康指标（焦虑、抑郁、性格优势）、生理指标（皮质醇唤醒反应 [CAR]、褪黑激素）和 QoL 评估。使用普通最小二乘法回归和量子回归对茁壮水平进行评估，以确定不同茁壮百分位数的预测因素：结果：心理健康是预测茁壮成长的最有力因素。抑郁会对较低水平的茁壮成长产生负面影响，而好奇心则会持续增强茁壮成长。CAR和褪黑激素分别对较高和中位数的茁壮成长水平起作用，而QoL对较低水平的茁壮成长水平影响最大。这些因素共同解释了 23.0% 的茁壮成长得分差异：本研究强调抑郁、好奇心、CAR 和 QoL 是影响青壮年癌症患者茁壮成长的关键因素。抑郁会在较低水平上影响患者的茁壮成长，好奇心会持续增强患者的茁壮成长，CAR 在较高水平上具有重要意义，而 QoL 在较低水平上至关重要。这些发现强调了有必要采取有针对性的干预措施，以支持不同适应水平的患者的茁壮成长。
What factors influence thriving in adolescent and young adult cancer patients? A focus on psychological health, biological markers, and quality of life.
Purpose: This study explores the role of psychological health, biological markers, and quality of life (QoL) in influencing thriving - defined as resilience and enhanced well-being - among adolescent and young adult (AYA) cancer patients.
Methods: A total of 148 AYA cancer patients were assessed for psychological health indicators (anxiety, depression, character strengths), physiological markers (cortisol awakening response [CAR], melatonin), and QoL. Thriving levels were evaluated using ordinary least squares regression and quantile regression to identify predictors across different thriving percentiles.
Results: Psychological health was the strongest predictor of thriving. Depression negatively impacted thriving at lower levels, while inquisitiveness consistently enhanced it. CAR and melatonin played roles at higher and median thriving levels, respectively, and QoL was most influential at lower levels. These factors collectively explained 23.0% of the variance in thriving scores.
Conclusions: This study highlights depression, inquisitiveness, CAR, and QoL as key factors influencing thriving in AYA cancer patients. Depression affects thriving at lower levels, inquisitiveness enhances thriving consistently, CAR is significant at higher levels, and QoL is crucial at lower levels. These findings underscore the need for tailored interventions to support thriving across varying levels of adaptation.
期刊介绍：
BMC Psychology is an open access, peer-reviewed journal that considers manuscripts on all aspects of psychology, human behavior and the mind, including developmental, clinical, cognitive, experimental, health and social psychology, as well as personality and individual differences. The journal welcomes quantitative and qualitative research methods, including animal studies.
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