LY6E作为多发性骨髓瘤相关骨病新的预后生物标志物

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Min Shi, Jing Li, Jing Wang, Ye Yao, Xuxing Shen, Yuan Xia, Ji Xu
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引用次数: 0

摘要

溶骨性骨病是多发性骨髓瘤(MM)的常见并发症,它会恶化患者的生活质量。在这项研究中,我们利用生物信息学分析从基因表达Omnibus (GEO)数据库中识别与MM骨病(MBD)相关的差异表达基因(DEGs)。Kaplan-Meier (K-M)曲线和Cox回归分析表明,关键分子淋巴细胞抗原6复合物(LY6E)与MM的进展、不良预后和MBD的形成密切相关。此外,我们证实高LY6E表达促进MM细胞增殖和体外破骨细胞分化。综上所述,这些发现可能阐明了LY6E在MBD形成中的理论基础,并将其确定为MM的近期治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LY6E as a new prognostic biomarker of multiple myeloma-related bone disease.

Osteolytic bone disease, which deteriorates the quality of life, is a prevalent complication of multiple myeloma (MM). In this study, we utilized bioinformatics analysis to identify the differentially expressed genes (DEGs) associated with MM bone disease (MBD) from the Gene Expression Omnibus (GEO) databases. Here, the Kaplan-Meier (K-M) curve and Cox regression analyses demonstrated that the key molecule lymphocyte antigen 6 complex (LY6E) was closely correlated with the MM progression, unfavorable prognosis and the formation of MBD. Furthermore, we confirmed that higher LY6E expression promoted MM cell proliferation and osteoclast differentiation in vitro. Taken together, these findings may illuminate the theoretical foundation for LY6E in MBD formation and identify it as a neoteric therapeutic target for MM.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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