{"title":"推进超分辨率显微镜：商业仪器的最新创新。","authors":"Louisa Mezache, Christophe Leterrier","doi":"10.1093/mam/ozaf004","DOIUrl":null,"url":null,"abstract":"<p><p>Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics with unprecedented detail. This review highlights the most recent developments in commercially available super-resolution microscopes, focusing on the most widely used techniques: confocal laser scanning systems, structured illumination microscopy (SIM), stimulated emission depletion (STED) microscopy, and single-molecule localization microscopy (SMLM). We detail the technological advancements of Confocal.NL's GAIA, Nikon's NSPARC, CSR Biotech's MI-SIM, Zeiss's Lattice SIM 5, Leica's STELLARIS STED, and abberior's STED and MINFLUX systems, as well as Abbelight's SAFe MN360 and Bruker's Vutara VXL SMLM platforms. These advancements address the need for enhanced resolution, reduced phototoxicity, and improved imaging capabilities in a range of sample types, while also aiming to enhance user friendliness.</p>","PeriodicalId":18625,"journal":{"name":"Microscopy and Microanalysis","volume":"31 2","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments.\",\"authors\":\"Louisa Mezache, Christophe Leterrier\",\"doi\":\"10.1093/mam/ozaf004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics with unprecedented detail. This review highlights the most recent developments in commercially available super-resolution microscopes, focusing on the most widely used techniques: confocal laser scanning systems, structured illumination microscopy (SIM), stimulated emission depletion (STED) microscopy, and single-molecule localization microscopy (SMLM). We detail the technological advancements of Confocal.NL's GAIA, Nikon's NSPARC, CSR Biotech's MI-SIM, Zeiss's Lattice SIM 5, Leica's STELLARIS STED, and abberior's STED and MINFLUX systems, as well as Abbelight's SAFe MN360 and Bruker's Vutara VXL SMLM platforms. These advancements address the need for enhanced resolution, reduced phototoxicity, and improved imaging capabilities in a range of sample types, while also aiming to enhance user friendliness.</p>\",\"PeriodicalId\":18625,\"journal\":{\"name\":\"Microscopy and Microanalysis\",\"volume\":\"31 2\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microscopy and Microanalysis\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1093/mam/ozaf004\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microscopy and Microanalysis","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1093/mam/ozaf004","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments.
Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics with unprecedented detail. This review highlights the most recent developments in commercially available super-resolution microscopes, focusing on the most widely used techniques: confocal laser scanning systems, structured illumination microscopy (SIM), stimulated emission depletion (STED) microscopy, and single-molecule localization microscopy (SMLM). We detail the technological advancements of Confocal.NL's GAIA, Nikon's NSPARC, CSR Biotech's MI-SIM, Zeiss's Lattice SIM 5, Leica's STELLARIS STED, and abberior's STED and MINFLUX systems, as well as Abbelight's SAFe MN360 and Bruker's Vutara VXL SMLM platforms. These advancements address the need for enhanced resolution, reduced phototoxicity, and improved imaging capabilities in a range of sample types, while also aiming to enhance user friendliness.
期刊介绍：
Microscopy and Microanalysis publishes original research papers in the fields of microscopy, imaging, and compositional analysis. This distinguished international forum is intended for microscopists in both biology and materials science. The journal provides significant articles that describe new and existing techniques and instrumentation, as well as the applications of these to the imaging and analysis of microstructure. Microscopy and Microanalysis also includes review articles, letters to the editor, and book reviews.
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