血清降钙素基因相关肽和I型干扰素在系统性红斑狼疮相关性头痛中的意义。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI:10.1177/09612033251332789
Shu Sugimoto, Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Ryota Takamatsu, Nobuyuki Yajima, Kunihiro Ichinose, Toshimasa Shimizu, Ryusuke Yoshimi, Takashi Kida, Takayuki Katsuyama, Yusuke Matsuo, Hiroshi Kajiyama, Ayuko Takatani, Yoshiki Sekijima
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引用次数: 0

摘要

目的:头痛是系统性红斑狼疮(SLE)患者常见的神经系统症状。降钙素基因相关肽(CGRP)是头痛的潜在化学介质,而I型干扰素(IFN)在SLE的免疫系统中起着关键作用。本研究探讨了CGRP和I型ifn作为SLE患者头痛生物标志物的意义。方法我们使用来自日本多中心队列和生物库的144例SLE患者的临床信息和血清样本。采用酶联免疫分析法测定血清CGRP、IFN-α和IFN-β水平,比较头痛患者、无头痛患者和20名健康对照(HC)的血清CGRP、IFN-α和IFN-β水平。这些水平是根据偏头痛残疾评估确定的由头痛引起的日常残疾的严重程度进行比较的。结果144例患者中,头痛60例(中位年龄42岁;56名女性),并且明显比没有头痛的患者年轻(中位年龄,49岁;77名女性)(p < .005)。两组SLE疾病活动指数2000的中位数得分均为4.0,差异无统计学意义,而头痛患者的光敏性明显高于无头痛患者(p < 0.05)。头痛、非头痛、HC患者血清CGRP、IFN-α水平无显著性差异。头痛患者血清IFN-β水平显著高于非头痛患者(p < 0.005),而头痛和非头痛患者血清IFN-β水平均显著低于HC患者(p < 0.005)。血清CGRP、IFN-α和IFN-β水平在与头痛相关的日常残疾严重程度上无显著差异。结论血清CGRP和I型IFNs水平可能与sled相关性头痛无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Implications of serum calcitonin gene-related peptide and type I interferon in systemic lupus erythematosus-associated headaches.

ObjectiveHeadache is a common neurological symptom in patients with systemic lupus erythematosus (SLE). Calcitonin gene-related peptide (CGRP) is a potential chemical mediator of headaches, while type I interferon (IFN) plays a pivotal role in the immune system of SLE. This study investigated the implications of CGRP and type I IFNs as headache biomarkers in patients with SLE.MethodsWe used clinical information and serum samples from 144 patients with SLE from a Japanese multicenter cohort and a biobank. Serum CGRP, IFN-α, and IFN-β levels, which were measured using enzyme-linked immunoassay, were compared among patients with headache, those without headache, and 20 healthy controls (HC). These levels were compared based on the severity of daily disability caused by headaches as determined using the Migraine Disability Assessment.ResultsOf the 144 patients, 60 had headache (median age, 42 years; 56 women) and were significantly younger than patients without headache (median age, 49 years; 77 women) (p < .005). Both groups had a median SLE Disease Activity Index 2000 score of 4.0, which was not significantly different, whereas photosensitivity was significantly more prevalent in patients with headache than in those without headache (p < .05). Serum CGRP and IFN-α levels were not significantly different between patients with headache, those without headache, and HC. Serum IFN-β levels were significantly higher in patients with headache than in those without headache (p < .005), while being significantly lower in both patients with and without headache than in HC (p < .005). No significant differences in serum CGRP, IFN-α and IFN-β levels were observed based on the severity of daily disability related to headaches.ConclusionSerum CGRP and type I IFNs levels may not be involved in SLE-associated headaches.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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