基于表型的阻塞性肥厚型心肌病切除术分类

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-03-26 DOI:10.1016/j.jacbts.2024.12.016

Hao Cui, Hao Nie, Congrui Wang, Ningning Zhang, Yifan Wang, Wendao Liu, Siyuan Huang, Xiao Chen, Hao Jia, Songren Shu, Mengxia Fu, Qian Zhao, Xiumeng Hua, Yuan Chang, Yunhu Song, Jiangping Song

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引用次数: 0

摘要

这项研究对接受室间隔减容治疗的患者的临床和病理信息中的变量进行了分区，以确定阻塞性肥厚型心肌病亚型。亚型 1 的特点是肌节突变携带者比例高，室间隔厚度最大。亚型 2 的特征是左心房增大和心房颤动患者比例高。亚型 3 的特点是左心室流出道梯度高、炎症细胞浸润严重、术后不良事件发生率高。这一发现在两个短期和长期随访的验证队列中得到了很好的重复。

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Phenotype-Based Classification of Obstructive Hypertrophic Cardiomyopathy Undergoing Myectomy.

This study partitioned variables derived from clinical and pathological information in patients who received septal reduction therapy to identify obstructive hypertrophic cardiomyopathy subtypes. Subtype 1 was characterized by a high percentage of sarcomere mutation carriers and the highest interventricular septal thickness. Subtype 2 was featured by left atrial enlargement and a high percentage of patients with atrial fibrillation. Subtype 3 was characterized by a high left ventricular outflow tract gradient, serious inflammatory cell infiltration, and a high incidence of postoperative adverse events. This finding has been well replicated in 2 validation cohorts with short- and long-term follow-up.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.