{"title":"基于动态共价键的姜黄素纳米组装增强肿瘤选择性光热治疗。","authors":"Jiamin Qin, Guojuan Fan, Yanna Lv, Junxiao Zhang, Shenglin Geng, Lan Ma, Ling Wang, Jiaxin Yang, Weifen Zhang, Yizhou Zhan, Xiaoji Wang, Jinlong Ma","doi":"10.2147/IJN.S512590","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Owing to the uneven distribution of photothermal agents (PTAs), photothermal therapy (PTT) can damage normal tissues. The dynamic reversible covalent bond, which can significantly improve the oxidation stability of the drug and the characteristics of responsive drug release, thus improving the conversion efficiency of the drug, is a feasible solution to enhance the selective PTT for tumor treatment.</p><p><strong>Methods: </strong>The nanoassembly loaded curcumin (Cur) with dynamic covalent boronate and encapsulated Indocyanine Green (ICG) in the phospholipid bilayer by dynamic self-assembly.</p><p><strong>Results: </strong>The pH-responsive dynamic covalent bond-based nanoassembly system has great selective release of drugs in the tumor microenvironment and photothermal conversion efficiency. Furthermore, LIP-C/I could increase the antitumor effect through the combination of PTT and chemotherapy (CT). The experiments in vitro and in vivo have demonstrated that LIP-C/I could enhance selective PTT for tumor treatment.</p><p><strong>Discussion: </strong>Our nanoassembly system provides an alternative approach for enhancing selective PTT for tumor treatment using dynamic covalent boronate.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"3861-3875"},"PeriodicalIF":6.6000,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967351/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dynamic Covalent Bond-Based Nanoassembly of Curcumin to Enhance the Selective Photothermal Therapy for Tumor Treatment.\",\"authors\":\"Jiamin Qin, Guojuan Fan, Yanna Lv, Junxiao Zhang, Shenglin Geng, Lan Ma, Ling Wang, Jiaxin Yang, Weifen Zhang, Yizhou Zhan, Xiaoji Wang, Jinlong Ma\",\"doi\":\"10.2147/IJN.S512590\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Owing to the uneven distribution of photothermal agents (PTAs), photothermal therapy (PTT) can damage normal tissues. The dynamic reversible covalent bond, which can significantly improve the oxidation stability of the drug and the characteristics of responsive drug release, thus improving the conversion efficiency of the drug, is a feasible solution to enhance the selective PTT for tumor treatment.</p><p><strong>Methods: </strong>The nanoassembly loaded curcumin (Cur) with dynamic covalent boronate and encapsulated Indocyanine Green (ICG) in the phospholipid bilayer by dynamic self-assembly.</p><p><strong>Results: </strong>The pH-responsive dynamic covalent bond-based nanoassembly system has great selective release of drugs in the tumor microenvironment and photothermal conversion efficiency. Furthermore, LIP-C/I could increase the antitumor effect through the combination of PTT and chemotherapy (CT). The experiments in vitro and in vivo have demonstrated that LIP-C/I could enhance selective PTT for tumor treatment.</p><p><strong>Discussion: </strong>Our nanoassembly system provides an alternative approach for enhancing selective PTT for tumor treatment using dynamic covalent boronate.</p>\",\"PeriodicalId\":14084,\"journal\":{\"name\":\"International Journal of Nanomedicine\",\"volume\":\"20 \",\"pages\":\"3861-3875\"},\"PeriodicalIF\":6.6000,\"publicationDate\":\"2025-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967351/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Nanomedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IJN.S512590\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"NANOSCIENCE & NANOTECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Nanomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJN.S512590","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"NANOSCIENCE & NANOTECHNOLOGY","Score":null,"Total":0}
Dynamic Covalent Bond-Based Nanoassembly of Curcumin to Enhance the Selective Photothermal Therapy for Tumor Treatment.
Introduction: Owing to the uneven distribution of photothermal agents (PTAs), photothermal therapy (PTT) can damage normal tissues. The dynamic reversible covalent bond, which can significantly improve the oxidation stability of the drug and the characteristics of responsive drug release, thus improving the conversion efficiency of the drug, is a feasible solution to enhance the selective PTT for tumor treatment.
Methods: The nanoassembly loaded curcumin (Cur) with dynamic covalent boronate and encapsulated Indocyanine Green (ICG) in the phospholipid bilayer by dynamic self-assembly.
Results: The pH-responsive dynamic covalent bond-based nanoassembly system has great selective release of drugs in the tumor microenvironment and photothermal conversion efficiency. Furthermore, LIP-C/I could increase the antitumor effect through the combination of PTT and chemotherapy (CT). The experiments in vitro and in vivo have demonstrated that LIP-C/I could enhance selective PTT for tumor treatment.
Discussion: Our nanoassembly system provides an alternative approach for enhancing selective PTT for tumor treatment using dynamic covalent boronate.
期刊介绍：
The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area.
With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field.
Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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