粪便生物标志物在预测印度儿童急性感染性腹泻侵袭性方面的实用性

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-04-04 DOI:10.1007/s13312-025-00030-8

Prabhav Aggarwal, Raghvendra Singh, Masoom Nathani, Sonal Saxena, Oves Siddiqui

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引用次数: 0

摘要

目的确定粪钙蛋白（FC）和粪乳铁蛋白（FL）在诊断侵袭性腹泻中的作用：采用湿装片显微镜、培养、多重聚合酶链反应、轮状病毒/腺病毒快速检测以及 FC 和 FL 定量 ELISA 分析 75 名急性腹泻儿童（≤ 12 岁）的粪便样本：平均（标清）FC水平（微克/克）[774（626.59） vs. 213（251.48），P 243微克/克（灵敏度81.57%，特异度67.56%，AUC 0.813），FL > 6.02微克/克（灵敏度71.05%，特异度81.08%，AUC 0.732）具有诊断潜力：结论：FC和FL可帮助诊断急性侵袭性腹泻。

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Utility of Fecal Biomarkers to Predict Invasive Nature of Acute Infectious Diarrhea in Indian Children.

Objective: To determine role of fecal calprotectin (FC) and fecal lactoferrin (FL) in diagnosis of invasive diarrhea.

Methods: Stool samples from 75 children (≤ 12 years) with acute diarrhea were analysed using wet mount microscopy, culture, multiplex polymerase chain reaction, rapid tests for Rotavirus/ Adenovirus and quantitative ELISA for FC and FL.

Results: The mean (SD) FC levels (μg/g) [774 (626.59) vs. 213 (251.48), P < 0.001] and FL levels (μg/g) [7.95 (4.72) vs. 4.22 (3.91), P = 0.004] were significantly higher in children with invasive diarrhea (n = 38) compared to those with non-invasive diarrhea (n = 37). Cut-off values of FC > 243 μg/g (sensitivity 81.57%, specificity 67.56%, AUC 0.813) and for FL > 6.02 μg/g (sensitivity 71.05%, specificity 81.08%, AUC 0.732) have diagnostic potential.

Conclusions: FC and FL can aid diagnosis of acute invasive diarrhea.

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.