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IF 3 3区医学 Q1 PEDIATRICS

European Journal of Pediatrics Pub Date : 2025-04-04 DOI:10.1007/s00431-025-06122-8

Teresa Fernandez Moreno, Aleksandra Kołcz, Maria Qaheri, Dawid Lewandowski, Artur Sulik, Kacper Toczyłowski

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引用次数: 0

摘要

本研究旨在调查 2020 年至 2023 年期间波兰东北部因急性肠胃炎（AGE）住院的儿童中弯曲杆菌和沙门氏菌感染的流行病学、季节性趋势和临床特征。这项研究旨在解决有关这些细菌病原体的本地化数据稀缺的问题，并确定关键的临床和人口学标记，以改进诊断和治疗策略。研究人员对在比亚韦斯托克儿童临床医院住院的 0-17 岁儿童的医疗记录进行了回顾性分析。按照世界卫生组织的指导方针，系统地采集了粪便样本并进行了细菌病原体检测。对确诊的弯曲杆菌和沙门氏菌感染病例进行了人口统计学、临床和实验室特征分析。在 3,392 名急性肠胃炎住院患儿中，有 560 例确定了细菌病原体，其中最常见的是弯曲杆菌（33%）和沙门氏菌（32%）。两种病原体均以男性居多。与弯曲菌相比，沙门氏菌感染的临床严重程度明显更高，表现为腹泻持续时间更长、呕吐频率更高、发热更持久、脱水更严重、炎症指标明显升高以及住院时间更长。弯曲菌在 2 岁以下儿童中的发病率明显更高。两种病原体的季节性发病高峰均出现在夏季：结论：弯曲杆菌和沙门氏菌是儿童细菌性 AGE 的主要致病菌，具有不同的临床和人口特征。公共卫生措施和强化诊断对于减轻这些感染的负担至关重要，尤其是在年幼和易受感染的儿童中：- 已知信息：弯曲杆菌和沙门氏菌是全球小儿肠胃炎的主要病因，具有季节性差异和临床严重性差异：- 新发现：在波兰东北部，弯曲杆菌和沙门氏菌导致的小儿 AGE 住院人数相似，尽管官方报告显示弯曲杆菌的发病率较低。- 沙门氏菌感染的临床症状要严重得多，但弯曲杆菌感染通常会影响所有年龄段的儿童，包括年仅 2 个月的婴儿。

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Campylobacter and Salmonella infections in children hospitalized with gastroenteritis in Northeastern Poland, 2020-2023.

This study aimed to investigate the epidemiology, seasonal trends, and clinical characteristics of Campylobacter and Salmonella infections in children hospitalized with acute gastroenteritis (AGE) in Northeastern Poland from 2020 to 2023. The research sought to address the scarcity of localized data on these bacterial pathogens and identify key clinical and demographic markers to improve diagnostic and therapeutic strategies. A retrospective analysis was conducted on medical records of children aged 0-17 years hospitalized at the Bialystok Children's Clinical Hospital. Stool samples were systematically collected and tested for bacterial pathogens following World Health Organization guidelines. Confirmed cases of Campylobacter and Salmonella infections were analyzed for demographic, clinical, and laboratory characteristics. Among 3,392 hospitalized children with acute gastroenteritis, bacterial pathogens were identified in 560 cases, with Campylobacter (33%) and Salmonella (32%) being the most common. A slight male predominance was noted across both pathogens. Salmonella infections were associated with significantly greater clinical severity, characterized by longer duration of diarrhea, higher frequency of vomiting, more persistent fever, greater dehydration, notably elevated inflammatory markers and longer hospital stays compared to Campylobacter. Campylobacter was notably more prevalent among children younger than 2 years. Seasonal peaks for both pathogens consistently occurred during the summer months.

Conclusion: Campylobacter and Salmonella are significant contributors to bacterial AGE in children, with distinct clinical and demographic profiles. Public health measures and enhanced diagnostics are critical to reducing the burden of these infections, particularly among younger and vulnerable children.

What is known: • Campylobacter and Salmonella are leading causes of pediatric gastroenteritis globally, with seasonal variation and clinical severity differences.

What is new: • In Northeastern Poland, Campylobacter and Salmonella cause similar numbers of pediatric AGE hospitalizations, despite official reports suggesting low Campylobacter incidence. • Salmonella infections are significantly more severe clinically, yet Campylobacter infections commonly affect children of all ages, including infants as young as 2 months.

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来源期刊

European Journal of Pediatrics 医学-小儿科

CiteScore

5.90

自引率

2.80%

发文量

367

审稿时长

3-6 weeks

期刊介绍： The European Journal of Pediatrics (EJPE) is a leading peer-reviewed medical journal which covers the entire field of pediatrics. The editors encourage authors to submit original articles, reviews, short communications, and correspondence on all relevant themes and topics. EJPE is particularly committed to the publication of articles on important new clinical research that will have an immediate impact on clinical pediatric practice. The editorial office very much welcomes ideas for publications, whether individual articles or article series, that fit this goal and is always willing to address inquiries from authors regarding potential submissions. Invited review articles on clinical pediatrics that provide comprehensive coverage of a subject of importance are also regularly commissioned. The short publication time reflects both the commitment of the editors and publishers and their passion for new developments in the field of pediatrics. EJPE is active on social media (@EurJPediatrics) and we invite you to participate. EJPE is the official journal of the European Academy of Paediatrics (EAP) and publishes guidelines and statements in cooperation with the EAP.