经口激光显微手术治疗局部晚期声门癌后的平衡生存率和生活质量。

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2025-04-04 DOI:10.1007/s00405-025-09349-1

Eduardo Breda, Joana Marques, Isabel Vasquez, Eurico Monteiro

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引用次数: 0

摘要

目的：本研究旨在分析一家三甲医院接受TOLM治疗的可切除T3-T4a声门癌患者，评估器官保留病例的生存率、功能和QoL：方法：确诊为喉声门鳞状细胞癌 pT3-pT4a 的患者：82例患者主要为男性，平均年龄为65.5岁。喉保留率为 76.83%。5年总生存率为68.3%，5年疾病特异性生存率为80.9%，5年局部无病生存率为91.2%。VHI-10中值为9.20（SD ± 5.90），近三分之二（63.33%）的患者得分正常。在 QLQ-C30 问卷中，六项功能评分中有五项超过 80 分。在 QLQ-HN43 中，所有量表（单项和多项目）的得分均低于 16.结论：结论：对于局部晚期声门癌，TOLM 的生存率与根治术和其他保留器官的方法相当，而且功能良好，术后症状轻微，嗓音损伤轻微。

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Balancing survival rates and quality-of-life outcomes after transoral laser microsurgery for locally advanced glottic cancer.

Purpose: This study aims to analyze resectable T3-T4a glottic cancer patients treated with TOLM at a tertiary hospital, evaluating survival, function, and QoL in organ-preserved cases.

Methods: Patients with diagnosis of laryngeal glottic squamous cell carcinoma pT3-pT4a N < 3 M0 treated with primary curative intention TOLM from 2005 to 2021 were included. Statistical analysis was performed, including survival rates. Quality of life was evaluated using VHI-10, EORTC-QLQ-C30 and EORTC-QLQ-HN43.

Results: 82 patients were included in this study, predominantly male, with a mean age of 65.5 years old. Laryngeal preservation rate was 76.83%. 5-year overall survival was 68.3%, 5-year Disease Specific Survival was 80.9%, 5-year Local disease-free survival was 91.2%. Medium VHI-10 score was 9.20 (SD ± 5.90), with nearly two thirds (63.33%) having a normal score. On the QLQ-C30 questionnaire, five of the six functional scales were over 80. On the QLQ-HN43 all the scales (single and multi-item) scored less than 16.

Conclusion: TOLM achieved comparable survival rates to radical surgery and other organ-preserving methods for locally advanced glottic cancer, as well as good functional outcomes with minimal post-surgical symptoms and mild voice impairment.

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.