阻塞性睡眠呼吸暂停对COVID-19住院患者结局的影响:2020年美国全国住院患者样本的倾向评分匹配分析

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1472176
Wei Du, Hong Xu, Yunqi Chang, Biying Feng, Qiong Wang, Weifeng Li
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引用次数: 0

摘要

背景:阻塞性睡眠呼吸暂停(OSA)与健康并发症相关,但其对COVID-19结局的影响尚不清楚。本研究探讨了阻塞性睡眠呼吸暂停与住院COVID-19患者预后的关系。方法:检索2020年全国住院患者样本,查找因COVID-19住院的成人。我们关注的结果是住院死亡率、非常规出院、住院时间延长(LOS)和并发症。根据年龄、性别和主要合并症,采用倾向评分匹配(PSM)将OSA患者与非OSA患者按1:4的比例进行匹配。结果:经PSM治疗后,成年COVID-19患者54,900例,其中OSA患者10,980例,非OSA患者43,920例。平均年龄63.2 岁,男性占62.8%。OSA患者发生呼吸衰竭(调整OR [aOR] = 1.20,95%可信区间[CI]: 1.14-1.25)、心力衰竭(aOR = 1.71,95% CI: 1.60-1.82)和心律失常(aOR = 1.18,95% CI: 1.08-1.30)的几率更高。相反,OSA与脑血管意外(CVAs)发生率较低相关(aOR = 0.71,95% CI: 0.62-0.81, p p p)结论:OSA与COVID-19住院患者发生呼吸衰竭、心力衰竭和心律失常的风险较高相关。然而,年龄≥70 岁的OSA患者和男性发生cva和住院死亡率的可能性较低。这些发现强调了OSA与COVID-19之间的复杂关系。由于这项研究的重点是住院患者,因此研究结果可能不适用于轻度或无症状的COVID-19病例。未来的研究应包括以社区为基础的队列和前瞻性研究,以更好地了解这种关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of obstructive sleep apnea on inpatient outcomes of COVID-19: a propensity-score matching analysis of the US Nationwide Inpatient Sample 2020.

Background: Obstructive sleep apnea (OSA) is associated with health complications, but its impact on COVID-19 outcomes is not known. This study investigated the association between OSA and outcomes of hospitalized COVID-19 patients.

Methods: The Nationwide Inpatient Sample 2020 was searched for adults hospitalized for COVID-19. The outcomes of interest were in-hospital mortality, non-routine discharge, prolonged length of stay (LOS), and complications. Patients with OSA were matched to those without OSA in a 1:4 ratio using propensity score matching (PSM) according to age, sex, and major comorbidities.

Results: After PSM, there were 54,900 adult COVID-19 patients consisting of 10,980 with OSA and 43,920 without OSA. The mean age was 63.2 years and 62.8% were male. Patients with OSA had higher odds of respiratory failure (adjusted OR [aOR] = 1.20, 95% confidence interval [CI]: 1.14-1.25), heart failure (aOR = 1.71, 95% CI: 1.60-1.82), and arrhythmias (aOR = 1.18, 95% CI: 1.08-1.30). Conversely, OSA was associated with lower odds of cerebrovascular accidents (CVAs) (aOR = 0.71, 95% CI: 0.62-0.81, p < 0.001), and a reduced likelihood of in-hospital mortality among patients ≥70 years old (aOR = 0.82, 95% CI: 0.75-0.89, p < 0.001) and males (aOR = 0.79, 95% CI: 0.72-0.88, p < 0.001), but not females.

Conclusion: OSA is associated with higher risks of respiratory failure, heart failure, and arrhythmias in patients hospitalized for COVID-19. However, patients with OSA who are ≥70 years old and those who are male are less likely to have CVAs and in-hospital mortality. These findings underscore the complex relationship between OSA and COVID-19. As the study focused on hospitalized patients, the findings may not apply to mild or asymptomatic COVID-19 cases. Future research should include community-based cohorts and prospective studies to better understand this association.

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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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