Audrey M Collins, Maddison L Mellow, Ashleigh E Smith, Lu Wan, Neha P Gothe, Jason Fanning, John M Jakicic, Chaeryon Kang, George Grove, Haiqing Huang, Lauren E Oberlin, Jairo H Migueles, M Ilyas Kamboh, Arthur F Kramer, Charles H Hillman, Eric D Vidoni, Jeffrey M Burns, Edward McAuley, Kirk I Erickson
{"title":"成年后期的24小时时间使用和认知表现:来自运动干预试验(IGNITE)研究中神经认知的调查收益的结果。","authors":"Audrey M Collins, Maddison L Mellow, Ashleigh E Smith, Lu Wan, Neha P Gothe, Jason Fanning, John M Jakicic, Chaeryon Kang, George Grove, Haiqing Huang, Lauren E Oberlin, Jairo H Migueles, M Ilyas Kamboh, Arthur F Kramer, Charles H Hillman, Eric D Vidoni, Jeffrey M Burns, Edward McAuley, Kirk I Erickson","doi":"10.1093/ageing/afaf072","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study examined associations between 24-hour time-use composition (i.e. sleep, sedentary time, light physical activity and moderate-to-vigorous physical activity) and cognitive performance and explored whether demographic or genetic factors moderated these relationships.</p><p><strong>Methods: </strong>This analysis included baseline data from cognitively unimpaired older adults (n = 648) enrolled in the Investigating Gains in Neurocognition in an Intervention Trial of Exercise study. Time use was measured using wrist-worn triaxial accelerometers. Cognitive domains were determined using a confirmatory factor analysis from a comprehensive neuropsychological battery. Linear regression models tested associations between time-use composition and cognitive factors, adjusting for age, sex, education, body mass index, apolipoprotein E4 (APOE4) allele carriage and study site. Interaction terms evaluated moderation of time use by age, sex, education and APOE4 status. We also examined the theoretical impact of reallocating time between time-use behaviours on cognitive performance using compositional isotemporal substitution methods.</p><p><strong>Results: </strong>Time-use composition was associated with processing speed (F = 5.16, P = .002), working memory (F = 4.81, P = .003) and executive function/attentional control (F = 7.09, P < .001) but not episodic memory (F = 2.28, P = .078) or visuospatial function (F = 2.26, P = .081). Post hoc isotemporal substitution analyses found that significant associations were driven by time spent in moderate-to-vigorous physical activity (MVPA), with lesser amounts of MVPA associated with poorer cognitive performance. There was no evidence of moderation by any tested factors.</p><p><strong>Conclusions: </strong>Increasing or decreasing MVPA, at the expense of time spent in sleep, sedentary behaviour or light physical activity, may be related to individual variation in processing speed, executive function/attentional control and working memory in older adulthood.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 4","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969675/pdf/","citationCount":"0","resultStr":"{\"title\":\"24-Hour time use and cognitive performance in late adulthood: results from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study.\",\"authors\":\"Audrey M Collins, Maddison L Mellow, Ashleigh E Smith, Lu Wan, Neha P Gothe, Jason Fanning, John M Jakicic, Chaeryon Kang, George Grove, Haiqing Huang, Lauren E Oberlin, Jairo H Migueles, M Ilyas Kamboh, Arthur F Kramer, Charles H Hillman, Eric D Vidoni, Jeffrey M Burns, Edward McAuley, Kirk I Erickson\",\"doi\":\"10.1093/ageing/afaf072\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This cross-sectional study examined associations between 24-hour time-use composition (i.e. sleep, sedentary time, light physical activity and moderate-to-vigorous physical activity) and cognitive performance and explored whether demographic or genetic factors moderated these relationships.</p><p><strong>Methods: </strong>This analysis included baseline data from cognitively unimpaired older adults (n = 648) enrolled in the Investigating Gains in Neurocognition in an Intervention Trial of Exercise study. 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引用次数: 0
摘要
目的:本横断面研究考察了24小时时间使用构成(即睡眠、久坐时间、轻度体育活动和中高强度体育活动)与认知表现之间的关系,并探讨了人口统计学或遗传因素是否会调节这些关系。方法:本分析包括来自认知功能未受损的老年人(n = 648)的基线数据,这些老年人参加了一项运动干预试验中的神经认知研究。使用腕带三轴加速度计测量时间使用情况。认知领域是通过综合神经心理学电池的验证性因素分析来确定的。线性回归模型检验了时间使用构成与认知因素之间的关系,调整了年龄、性别、教育程度、体重指数、载脂蛋白E4 (APOE4)等位基因携带和研究地点。相互作用项根据年龄、性别、教育程度和APOE4状态评估时间使用的适度性。我们还研究了时间使用行为之间重新分配时间对认知表现的理论影响,使用组成等时间替代方法。结果:时间使用构成与加工速度(F = 5.16, P = 0.002)、工作记忆(F = 4.81, P = 0.003)和执行功能/注意控制(F = 7.09, P)相关。结论:以睡眠时间、久坐行为或轻体力活动为代价的MVPA的增加或减少可能与老年人加工速度、执行功能/注意控制和工作记忆的个体差异有关。
24-Hour time use and cognitive performance in late adulthood: results from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study.
Objective: This cross-sectional study examined associations between 24-hour time-use composition (i.e. sleep, sedentary time, light physical activity and moderate-to-vigorous physical activity) and cognitive performance and explored whether demographic or genetic factors moderated these relationships.
Methods: This analysis included baseline data from cognitively unimpaired older adults (n = 648) enrolled in the Investigating Gains in Neurocognition in an Intervention Trial of Exercise study. Time use was measured using wrist-worn triaxial accelerometers. Cognitive domains were determined using a confirmatory factor analysis from a comprehensive neuropsychological battery. Linear regression models tested associations between time-use composition and cognitive factors, adjusting for age, sex, education, body mass index, apolipoprotein E4 (APOE4) allele carriage and study site. Interaction terms evaluated moderation of time use by age, sex, education and APOE4 status. We also examined the theoretical impact of reallocating time between time-use behaviours on cognitive performance using compositional isotemporal substitution methods.
Results: Time-use composition was associated with processing speed (F = 5.16, P = .002), working memory (F = 4.81, P = .003) and executive function/attentional control (F = 7.09, P < .001) but not episodic memory (F = 2.28, P = .078) or visuospatial function (F = 2.26, P = .081). Post hoc isotemporal substitution analyses found that significant associations were driven by time spent in moderate-to-vigorous physical activity (MVPA), with lesser amounts of MVPA associated with poorer cognitive performance. There was no evidence of moderation by any tested factors.
Conclusions: Increasing or decreasing MVPA, at the expense of time spent in sleep, sedentary behaviour or light physical activity, may be related to individual variation in processing speed, executive function/attentional control and working memory in older adulthood.
期刊介绍:
Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.