DCTPP1：通过核苷酸代谢在癌症治疗和预后中有前景的靶点。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-04-01 DOI:10.1016/j.drudis.2025.104348

Shaoxuan Liu, Li Feng, Zhe Wang

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引用次数: 0

摘要

脱氧胞苷三磷酸焦磷酸酶1 （DCTPP1）是一种重要的脱氧胞苷三磷酸（dCTP）水解酶，负责消除非规范的dCTP和维持脱氧核糖核苷三磷酸（dNTP）池的稳态。这种调节对于DNA的正常复制和基因组的稳定至关重要。新出现的证据强调了DCTPP1在肿瘤进展、化疗耐药和预后预测中的重要作用。因此，DCTPP1已成为一个有希望的核苷酸代谢相关的癌症治疗靶点。在这篇综述中，我们就DCTPP1的结构和细胞生物学特征、功能及其在癌症中的作用进行了全面的综述。此外，我们还讨论了靶向DCTPP1的小分子药物的最新研究进展，并提出了未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

DCTPP1: A promising target in cancer therapy and prognosis through nucleotide metabolism

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DCTPP1: A promising target in cancer therapy and prognosis through nucleotide metabolism

Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) is an important deoxycytidine triphosphate (dCTP) hydrolase responsible for eliminating noncanonical dCTP and maintaining deoxyribonucleoside triphosphate (dNTP) pool homeostasis. This regulation is vital for proper DNA replication and genome stability. Emerging evidence highlights the considerable role of DCTPP1 in tumor progression, chemotherapy resistance, and prognostic prediction. Consequently, DCTPP1 has emerged as a promising nucleotide metabolism-related target for cancer therapy. In this review, we provide a comprehensive summary of the structural and cellular biological features of DCTPP1, its functions, and its role in cancer. In addition, we discuss recent advancments in small molecules targeting DCTPP1, and propose potential directions for future research.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.