生物信息学分析鉴定针对子宫内膜异位症基因的环境内分泌化学物质

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-04-05 DOI:10.1016/j.ecoenv.2025.118136

Kaile Du , Haiwei Xiong , Xiangcheng Zhang , Ruihang Luo , Boxuan Zhou

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引用次数: 0

摘要

子宫内膜异位症（EMS）严重影响妇女的健康，并受到遗传因素和环境内分泌干扰化学物质（EDCs）的影响，这些化学物质会干扰荷尔蒙平衡。利用基因表达Omnibus数据库，我们鉴定了差异表达基因，并应用WGCNA、GO、KEGG和LASSO回归等分析方法，预测了与EMS相关的6个关键基因：ADAM9、IRAK3、NTRK3、PIK3CG、STK38和TLR4。通过整合比较毒物基因组学数据库和内分泌干扰交换数据库，我们确定了35种可能与这些基因相关的EDCs。这项研究强调了EMS和EDCs之间的关系，为其发病机制和改善治疗的潜在治疗靶点提供了见解。

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Bioinformatics analysis to identify environmental endocrine chemicals that target endometriosis genes

Endometriosis (EMS) significantly impacts women's health and is influenced by genetic factors and environmental endocrine-disrupting chemicals (EDCs), which interfere with hormonal balance. Using the Gene Expression Omnibus database, we identified differentially expressed genes and applied analytical methods, including WGCNA, GO, KEGG, and LASSO regression, to predict six key genes associated with EMS: ADAM9, IRAK3, NTRK3, PIK3CG, STK38, and TLR4. By integrating the Comparative Toxicogenomics Database and Endocrine Disruption Exchange Database, we identified 35 EDCs potentially linked to these genes. This study highlights the relationship between EMS and EDCs, offering insights into its pathogenesis and potential therapeutic targets for improved treatment.

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.