在没有相转移催化剂的情况下，位于两个不混相液相中的物质之间形成酰胺键

IF 1.6 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry Pub Date : 2025-03-30 DOI:10.1016/j.ijms.2025.117443

Xiao-Fei Gao , Wei Xiao , Meng Qiu , Zhi-Gang Cheng , Xiang-Zhao Chen

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引用次数: 0

摘要

两种不混溶液体中物质之间有效的酰胺键构建是两种性质完全不同的物质共价结合的关键。在此，我们证明了位于两种不混溶溶液中的物质之间的氨解反应可以在没有相转移催化剂的微滴中促进，从而导致酰胺键形成产物。此外，在微滴双相反应中，活化酯中疏水性基团的大小和烷基链的长度对氨解反应也有很大影响。该结果将为两种不混相物质之间的界面微滴反应提供进一步的认识，并为两种性质完全不同的物质的连接提供新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Amide bond formation between substances located in two immiscible liquid phases without phase-transfer catalyst

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Amide bond formation between substances located in two immiscible liquid phases without phase-transfer catalyst

Effectively amide bond construction between substances located in two immiscible liquids is a key point in the covalent-combination of the two parts with totally different characters. Herein, we demonstrated that aminolysis reactions between substances located in two immiscible solutions can be promoted in microdroplets without phase transfer catalyst, leading to amide bond formation products. Furthermore, in the biphasic reaction of microdroplets, size of the hydrophobic group and length of the alkyl chain in an activated ester may also affect a lot on the aminolysis reaction. This result will provide us a further insight on interfacial microdroplet reaction between substances located in two immiscible liquid phases and a new approach for ligation of two substances with totally different properties.

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来源期刊

International Journal of Mass Spectrometry 物理-光谱学

CiteScore

3.60

自引率

5.60%

发文量

145

审稿时长

71 days

期刊介绍： The journal invites papers that advance the field of mass spectrometry by exploring fundamental aspects of ion processes using both the experimental and theoretical approaches, developing new instrumentation and experimental strategies for chemical analysis using mass spectrometry, developing new computational strategies for data interpretation and integration, reporting new applications of mass spectrometry and hyphenated techniques in biology, chemistry, geology, and physics. Papers, in which standard mass spectrometry techniques are used for analysis will not be considered. IJMS publishes full-length articles, short communications, reviews, and feature articles including young scientist features.