碱[4+3]环加成法合成苯并[e][1,2,4]三氮平-5- 1

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-03 DOI:10.1016/j.tet.2025.134595

Eeda lingareddy , Ravindra M. Kumbhare

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引用次数: 0

摘要

在此，我们报告了通过肼酰氯和异酸酐的碱[4 + 3]环加成法合成高官能化苯并[e][1,2,4]三氮杂卓-5-酮的过程。该反应是通过容易获得的肼酰氯原位生成腈亚胺进行的。一种简单的有机碱三乙基胺成功地推动了反应的进行，以极好的收率得到了所需的产物。广泛的底物范围充分证明了 [4 + 3] 环加成过程的稳健性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Facile synthesis of benzo[e][1,2,4]triazepin-5-ones through a base medicated [4+3] cycloaddition

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Facile synthesis of benzo[e][1,2,4]triazepin-5-ones through a base medicated [4+3] cycloaddition

Herein, we report the synthesis of highly functionalized benzo[e][1,2,4]triazepin-5-ones through a base medicated [4 + 3] cycloaddition of hydrazonoyl chloride and isatoic anhydride. The reaction proceeds through in situ generated nitrile imines from easily accessible hydrazonoyl chlorides. a simple organic base triethyl amine drives the reaction very successfully to give the desired products in excellent yields. The robustness of the [4 + 3] cycloaddition process is well evidented by broad substrate scope.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.