环境空气污染物对心血管疾病住院治疗的短期和滞后影响：德黑兰一项为期20年的基于人群的研究

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health Pub Date : 2025-04-04 DOI:10.1016/j.ijheh.2025.114573

Alireza Khajavi , Navid Ebrahimi , Soroush Masrouri , Mitra Hasheminia , Fereidoun Azizi , Davood Khalili , Farzad Hadaegh

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引用次数: 0

摘要

目的探讨短期接触环境空气污染物与心血管疾病（CVD）住院的关系。方法对来自德黑兰第13区3454名50-70岁居民（1880名女性）的德黑兰血脂和血糖研究队列数据进行时间序列分析。对1999年1月至2018年3月的随访数据进行分析。记录了日平均气温和空气污染水平（CO、O3、PM10、NO2和SO2），并使用分布滞后非线性模型（DLNMs）评估了对结果的滞后影响。结果在14.7年的中位随访中，3454名参与者（平均年龄58.7岁，女性= 1880）中发生2200例心血管疾病住院。在普通人群中，DLNM模型显示，PM10浓度为73 μg/m3时，结果风险增加12%，RR为1.12 (95% CI: 1.01-1.24)，较高的PM10水平对应于增加的RR。PM10表明在1天后的短期暴露对结果风险有影响。SO2浓度在24 μg/m3时达到显著性，RR为1.06 (95% CI: 1.04 ~ 1.07)；这种效果持续到65 μg/m3, 6天后观察到的结果风险增加。CO浓度为5 mg/m3时，相对危险度最高，为1.92 （95% CI: 1.65 ~ 2.23）。暴露于一氧化碳与1天滞后的结果风险增加有关。性别以及代谢综合征和慢性肾病的存在并没有改变空气污染物与结果之间的关系。结论短期暴露于PM10、SO2和CO环境可显著增加心血管疾病住院风险。

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Short-term and lagged effects of ambient air pollutants on CVD hospitalization: A two-decade population-based study in Tehran

Objectives

To evaluate the relationship between short-term exposure to ambient air pollutants and cardiovascular disease (CVD) hospitalizations.

Methods

A time-series analysis was conducted using data from the Tehran Lipid and Glucose Study cohort of 3454 residents (1880 women) aged 50–70 from District 13 of Tehran. Follow-up data from January 1999 to March 2018 were analyzed. Daily mean temperatures and air pollution levels (CO, O₃, PM₁₀, NO₂, and SO₂) were recorded, and distributed lag non-linear models (DLNMs) assessed the lagged effects on outcome.

Results

Over a median follow-up of 14.7 years, 2200 CVD hospitalizations occurred among 3454 participants (mean age 58.7 years, women = 1880). Among the general population, the DLNM models indicated that PM10 concentrations at 73 μg/m³ was associated with a 12 % increased risk of the outcome, with an RR of 1.12 (95 % CI: 1.01–1.24), and higher PM10 levels corresponded to increasing RRs. PM10 indicated a short-term exposure effect at 1-day lag on the outcome risk. SO₂ concentrations reached significance at 24 μg/m³, with an RR of 1.06 (95 % CI: 1.04–1.07); the effect persisted up to 65 μg/m³, with an increased risk of the outcome observed at a 6-day lag. CO showed the highest RR of 1.92 (95 % CI: 1.65–2.23) for the concentration of 5 mg/m3. Exposure to CO was linked to an increased risk of the outcome with a 1-day lag. Sex as well as presence of metabolic syndrome and CKD did not modify the association between air pollutants with the outcome.

Conclusions

Short-term exposure to PM10, SO2 and CO significantly increased risk of CVD hospitalization.

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来源期刊

International journal of hygiene and environmental health 医学-传染病学

CiteScore

11.50

自引率

5.00%

发文量

151

审稿时长

22 days

期刊介绍： The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.