Anders Kämpe, Sanna Gudmundsson, Colum P. Walsh, Kerstin Lindblad-Toh, Åsa Johansson, Anna Clareborn, Adam Ameur, Anders Edsjö, Thoas Fioretos, Hans Ehrencrona, Daniel Eriksson, Tove Fall, Paul W. Franks, Ulf Gyllensten, Margareta Haag, Anna Hagwall, Maria Johansson Soller, Janne Lehtiö, Yi Lu, Patrik K. E. Magnusson, Erik Melén, Beatrice Melin, Karl Michaëlsson, Ann Nordgren, Jessica Nordlund, Lao H. Saal, Jochen M. Schwenk, Per Sikora, Johan Sundström, Fulya Taylan, Bethany Van Guelpen, Mia Wadelius, Anna Wedell, Valtteri Wirta, Päivi Östling, Bo Jacobsson, Tobias Sjöblom, Bengt Persson, Richard Rosenquist, Anna Lindstrand, Tuuli Lappalainen
{"title":"瑞典精密组学计划（PROMISE）将把研究与医疗保健结合起来","authors":"Anders Kämpe, Sanna Gudmundsson, Colum P. Walsh, Kerstin Lindblad-Toh, Åsa Johansson, Anna Clareborn, Adam Ameur, Anders Edsjö, Thoas Fioretos, Hans Ehrencrona, Daniel Eriksson, Tove Fall, Paul W. Franks, Ulf Gyllensten, Margareta Haag, Anna Hagwall, Maria Johansson Soller, Janne Lehtiö, Yi Lu, Patrik K. E. Magnusson, Erik Melén, Beatrice Melin, Karl Michaëlsson, Ann Nordgren, Jessica Nordlund, Lao H. Saal, Jochen M. Schwenk, Per Sikora, Johan Sundström, Fulya Taylan, Bethany Van Guelpen, Mia Wadelius, Anna Wedell, Valtteri Wirta, Päivi Östling, Bo Jacobsson, Tobias Sjöblom, Bengt Persson, Richard Rosenquist, Anna Lindstrand, Tuuli Lappalainen","doi":"10.1038/s41591-025-03631-9","DOIUrl":null,"url":null,"abstract":"<p>Data-driven research and precision ‘-omics’ technologies have immense transformative potential to provide tailored treatment and care, embodying the principles of precision medicine. Sweden is a global leader in adopting genomic tools in healthcare. Still, national research datasets from human cohorts are too fragmented or too small to meet the needs of modern precision ‘-omics’ research. This positions Sweden behind its peer countries, with unmet research and healthcare implementation opportunities. However, the country is exceptionally well placed to change course, expand research data resources and adopt unique designs that integrate research and healthcare.</p><p>Here, we present Precision Omics Initiative Sweden (PROMISE)<sup>1</sup> and its three pillars: to generate extensive new large-scale multi-omics data with integration of selected existing research, registry and healthcare data; to maximize research use of ‘-omics’ data created in healthcare; and to develop an improved data-access framework.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"22 1","pages":""},"PeriodicalIF":58.7000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare\",\"authors\":\"Anders Kämpe, Sanna Gudmundsson, Colum P. 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Still, national research datasets from human cohorts are too fragmented or too small to meet the needs of modern precision ‘-omics’ research. This positions Sweden behind its peer countries, with unmet research and healthcare implementation opportunities. However, the country is exceptionally well placed to change course, expand research data resources and adopt unique designs that integrate research and healthcare.</p><p>Here, we present Precision Omics Initiative Sweden (PROMISE)<sup>1</sup> and its three pillars: to generate extensive new large-scale multi-omics data with integration of selected existing research, registry and healthcare data; to maximize research use of ‘-omics’ data created in healthcare; and to develop an improved data-access framework.</p>\",\"PeriodicalId\":19037,\"journal\":{\"name\":\"Nature Medicine\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":58.7000,\"publicationDate\":\"2025-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41591-025-03631-9\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41591-025-03631-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare
Data-driven research and precision ‘-omics’ technologies have immense transformative potential to provide tailored treatment and care, embodying the principles of precision medicine. Sweden is a global leader in adopting genomic tools in healthcare. Still, national research datasets from human cohorts are too fragmented or too small to meet the needs of modern precision ‘-omics’ research. This positions Sweden behind its peer countries, with unmet research and healthcare implementation opportunities. However, the country is exceptionally well placed to change course, expand research data resources and adopt unique designs that integrate research and healthcare.
Here, we present Precision Omics Initiative Sweden (PROMISE)1 and its three pillars: to generate extensive new large-scale multi-omics data with integration of selected existing research, registry and healthcare data; to maximize research use of ‘-omics’ data created in healthcare; and to develop an improved data-access framework.
期刊介绍：
Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors.
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Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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