{"title":"万古霉素敏感粪肠球菌中vanA基因的检测：附加检测的意义。","authors":"Victoria Jordan, Hemalatha Varadhan","doi":"10.1099/acmi.0.000959.v4","DOIUrl":null,"url":null,"abstract":"<p><p>To assess the frequency of silent vancomycin resistance, phenotypically susceptible <i>Enterococcus faecium</i> isolates underwent genotypic testing using Cepheid's Xpert <i>vanA</i>/<i>vanB</i> PCR. A total of 6% of isolates had silent <i>vanA</i> genes. However, the clinical relevance of silent <i>van</i> genes and the lack of rapid, random-access genotypic methods poses an ongoing challenge to laboratories.</p>","PeriodicalId":94366,"journal":{"name":"Access microbiology","volume":"7 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960786/pdf/","citationCount":"0","resultStr":"{\"title\":\"Detection of vanA genes in vancomycin-susceptible Enterococcus faecium isolates: implications for additional testing.\",\"authors\":\"Victoria Jordan, Hemalatha Varadhan\",\"doi\":\"10.1099/acmi.0.000959.v4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>To assess the frequency of silent vancomycin resistance, phenotypically susceptible <i>Enterococcus faecium</i> isolates underwent genotypic testing using Cepheid's Xpert <i>vanA</i>/<i>vanB</i> PCR. A total of 6% of isolates had silent <i>vanA</i> genes. However, the clinical relevance of silent <i>van</i> genes and the lack of rapid, random-access genotypic methods poses an ongoing challenge to laboratories.</p>\",\"PeriodicalId\":94366,\"journal\":{\"name\":\"Access microbiology\",\"volume\":\"7 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960786/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Access microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1099/acmi.0.000959.v4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Access microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1099/acmi.0.000959.v4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Detection of vanA genes in vancomycin-susceptible Enterococcus faecium isolates: implications for additional testing.
To assess the frequency of silent vancomycin resistance, phenotypically susceptible Enterococcus faecium isolates underwent genotypic testing using Cepheid's Xpert vanA/vanB PCR. A total of 6% of isolates had silent vanA genes. However, the clinical relevance of silent van genes and the lack of rapid, random-access genotypic methods poses an ongoing challenge to laboratories.
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