Antoine Avignon, Jean-Baptiste Bonnet, Jean Anitcheou, Sarah Tournayre, Vincent Attalin, Catherine Boegner, Abdulkader Jalek, Dominique Jullien, Camille Le Rouzic, Justine Myzia, Lucile Marty, Youadigue Kemba, Ariane Sultan, Jean Bousquet
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Using data from the Aviitam platform in France, this study aimed to do the following: 1) explore psychological and behavioral patterns through clustering techniques; 2) validate the robustness of these clusters; and 3) assess their association with weight-loss outcomes in severe obesity under semaglutide treatment.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Phase 1 included 989 adults with BMI ≥ 25 kg/m<sup>2</sup> who completed validated questionnaires, including the Hospital Anxiety and Depression Scale (HADS) and Intuitive Eating Scale-2 (IES-2). Phase 2 validated robustness in 492 individuals. Phase 3 applied clusters to 125 individuals with BMI ≥ 40 kg/m<sup>2</sup> who were treated with semaglutide 2.4 mg/week at Montpellier University Hospital, assessing weight-loss trajectories over 12 months.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The following two clusters were identified: the Intuitive Eaters Group (IEG, <i>n</i> = 482); and the Emotionally Driven Eaters Group (EDEG, <i>n</i> = 507). The IEG exhibited lower emotional distress and higher intuitive eating scores. HADS and IES-2 distinguished clusters effectively (area under the curve, 0.95). Robustness was confirmed in Phase 2. In Phase 3, the IEG demonstrated a significantly more favorable weight-loss trajectory compared to the EDEG (<i>p</i> = 0.03).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Psychological and behavioral clusters identified through HADS and IES-2 are associated with weight loss under semaglutide treatment, suggesting the value of integrating psychological and behavioral profiling into obesity care.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 5","pages":"892-902"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24262","citationCount":"0","resultStr":"{\"title\":\"Clustering of intuitive eating and psychological health identifies subgroups associated with weight loss following semaglutide\",\"authors\":\"Antoine Avignon, Jean-Baptiste Bonnet, Jean Anitcheou, Sarah Tournayre, Vincent Attalin, Catherine Boegner, Abdulkader Jalek, Dominique Jullien, Camille Le Rouzic, Justine Myzia, Lucile Marty, Youadigue Kemba, Ariane Sultan, Jean Bousquet\",\"doi\":\"10.1002/oby.24262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Obesity management requires personalized approaches. 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引用次数: 0
摘要
目的：肥胖管理需要个性化的方法。利用法国Aviitam平台的数据，本研究旨在：1)通过聚类技术探索心理和行为模式；2)验证这些聚类的鲁棒性；3)评估它们与西马鲁肽治疗下重度肥胖患者减肥结果的相关性。方法：第一阶段纳入989名BMI≥25 kg/m2的成年人，他们完成了包括医院焦虑和抑郁量表（HADS）和直觉饮食量表-2 （IES-2）在内的有效问卷。第二阶段在492个个体中验证了稳健性。在蒙彼利埃大学医院，125名BMI≥40 kg/m2的患者接受了semaglutide 2.4 mg/周的治疗，在3期研究中评估了12个月的体重减轻轨迹。结果：分为两类：直观食客组（IEG, n = 482）；情感驱动型饮食组（EDEG, n = 507）。IEG表现出较低的情绪困扰和较高的直觉饮食得分。HADS和IES-2能有效区分聚类（曲线下面积为0.95）。稳健性在第2期得到证实。在第3阶段，与EDEG相比，IEG表现出更有利的减肥轨迹（p = 0.03）。结论：通过HADS和IES-2识别的心理和行为聚类与西马鲁肽治疗下的体重减轻有关，表明将心理和行为分析纳入肥胖护理的价值。
Clustering of intuitive eating and psychological health identifies subgroups associated with weight loss following semaglutide
Objective
Obesity management requires personalized approaches. Using data from the Aviitam platform in France, this study aimed to do the following: 1) explore psychological and behavioral patterns through clustering techniques; 2) validate the robustness of these clusters; and 3) assess their association with weight-loss outcomes in severe obesity under semaglutide treatment.
Methods
Phase 1 included 989 adults with BMI ≥ 25 kg/m2 who completed validated questionnaires, including the Hospital Anxiety and Depression Scale (HADS) and Intuitive Eating Scale-2 (IES-2). Phase 2 validated robustness in 492 individuals. Phase 3 applied clusters to 125 individuals with BMI ≥ 40 kg/m2 who were treated with semaglutide 2.4 mg/week at Montpellier University Hospital, assessing weight-loss trajectories over 12 months.
Results
The following two clusters were identified: the Intuitive Eaters Group (IEG, n = 482); and the Emotionally Driven Eaters Group (EDEG, n = 507). The IEG exhibited lower emotional distress and higher intuitive eating scores. HADS and IES-2 distinguished clusters effectively (area under the curve, 0.95). Robustness was confirmed in Phase 2. In Phase 3, the IEG demonstrated a significantly more favorable weight-loss trajectory compared to the EDEG (p = 0.03).
Conclusions
Psychological and behavioral clusters identified through HADS and IES-2 are associated with weight loss under semaglutide treatment, suggesting the value of integrating psychological and behavioral profiling into obesity care.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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