Helen Pasternack, Jutta Kirfel
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引用次数: 0

摘要

在肺癌的分类中,小细胞癌和非小细胞癌的基本划分仍然适用。尽管组织学亚型相同,但众所周知,肿瘤细胞中存在明确的遗传变化,这些变化作为 "驱动因素 "对肿瘤的生长起着重要的决定作用,因此阻断这些变化会对临床病程产生重大影响。因此,在过去 10 年中,肺癌的治疗越来越多地辅以肿瘤特异性靶向药物和免疫调节方法。这一发展促使治疗方法日益差异化和个体化。病理学,尤其是分子病理诊断在这方面发挥着核心作用,因为必须对越来越多的生物标志物进行检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Molecular pathology in non-small-cell lung cancer: current and emerging biomarkers].

In the classification of lung cancer, the basic division into small cell and non-small cell carcinomas continues to apply. Despite the same histological subtyping, it is known that there are defined genetic changes in the tumor cells that significantly determine tumor growth as "drivers", so that their blockade can significantly influence the clinical course. Thus, in the last 10 years, the treatment of lung cancer has been increasingly supplemented by the establishment of tumor-specific targeted drugs and immunomodulatory approaches. This development has led to increasingly differentiated and individualized approaches to treatment. Pathology and especially molecular pathological diagnostics play a central role here, as an increasing number of biomarkers must be examined.

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