亨廷顿病患者的自杀倾向和睡眠障碍：来自 HDBOI 研究的证据

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurology. Clinical practice Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI:10.1212/CPJ.0000000000200461

Idaira Rodríguez Santana, Samuel A Frank, Tiago A Mestre, Astri Arnesen, Jamie L Hamilton, Hayley Hubberstey, Michaela Winkelmann, Elena Hernandez-Jimenez, Jeff Frimpter, Ricardo Dolmetsch, Talaha M Ali

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引用次数: 0

摘要

背景和目的：自杀意念和睡眠障碍在亨廷顿病（PwHD）患者中比其他健康同龄人更常见；然而，这些挑战的范围和程度并没有得到很好的理解。本研究利用亨廷顿病疾病负担（HDBOI）研究的数据，评估了欧洲和美国PwHD患者的自杀念头和睡眠障碍。方法：HDBOI研究是一项在法国、德国、意大利、西班牙、英国和美国进行的PwHD的疾病负担横断面研究。符合条件的参与者是在研究招募前≥12个月患有运动显性亨廷顿病（HD）的成年人（18岁及以上）。根据治疗医师的报告，PwHD分为早期（ES）、中期（MS）或晚期（as） HD。数据由医生收集，并由PwHD或护理人员填写自愿问卷。对所有结果进行描述性分析。采用方差分析或χ2检验评估差异。结果：共纳入PwHD 2,094例；1602例（77%）来自欧洲，492例（23%）来自美国，其中ES 846例（40%），MS 701例（33%），AS HD 547例（26%）。PwHD患者报告当前（13%,n = 272）或既往（28%,n = 575）有自杀意念，晚期HD患者更常见(ES, 11%；女士,14%;, 15%;P < 0.05)。在482名受访者中，91% （n = 437）报告睡眠困难，这在AS - HD患者中更为常见(p < 0.05；[p = 0.000])。讨论：HDBOI研究显示，PwHD患者存在自杀意念和睡眠障碍的沉重负担，且随着疾病严重程度的加重，这些负担趋于恶化。

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Suicidal Ideation and Sleep Disturbances Among People With Huntington Disease: Evidence From the HDBOI Study.

Background and objectives: Suicidal ideation and sleep disturbances are more common among people with Huntington disease (PwHD) than otherwise healthy peers; however, the scope and magnitude of these challenges are not well understood. This study evaluated suicidal thoughts and sleep disturbances among PwHD in Europe and the United States using data from the Huntington's Disease Burden of Illness (HDBOI) study.

Methods: The HDBOI study is a cross-sectional burden-of-illness study of PwHD in France, Germany, Italy, Spain, the United Kingdom, and the United States. Eligible participants were adults (18 years and older) with motor manifest Huntington disease (HD) ≥ 12 months before study recruitment. PwHD were categorized as having early-stage (ES), mid-stage (MS), or advanced-stage (AS) HD as reported by the treating physician. Data were collected by the physician, and a voluntary questionnaire was completed by the PwHD or a caregiver. All findings were analyzed descriptively. Differences were assessed using analysis of variance or χ² tests.

Results: A total of 2,094 PwHD were included; 1,602 (77%) were from Europe and 492 (23%) were from the United States, with 846 (40%) with ES, 701 (33%) with MS, and 547 (26%) with AS HD. PwHD reported current (13%, n = 272) or previous (28%, n = 575) suicidal ideation, which was more common with advanced HD (ES, 11%; MS, 14%; AS, 15%; p < 0.05). Of 482 questionnaire respondents, 91% (n = 437) reported difficulty sleeping, which was more common with AS HD (p < 0.05; [p = 0.000]).

Discussion: The HDBOI study showed a substantial burden of suicidal ideation and sleep disturbances among PwHD, which tended to worsen with disease severity.

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.