再生医学:周围神经损伤与修复的新视野。

IF 1.4 Q3 ORTHOPEDICS
Orthopedic Reviews Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI:10.52965/001c.133572
Wahyu Widodo, Dina Aprilya, Oryza Satria
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引用次数: 0

摘要

周围神经损伤是患者的一大负担,也是对临床医生的一大挑战。在完全性损伤(轴索损伤或神经损伤)中,修复或重建后神经再生的缓慢性质很难赶上靶器官的退化速度,导致预后不良。目前再生医学的进展表明,干细胞及其产物在治疗包括神经在内的许多人体结构方面具有巨大的潜力。使用基于互联网的搜索引擎进行了全面的文献检索,以了解再生医学增强周围神经修复或重建的最新进展。干细胞可分化为神经细胞,具有旁分泌和免疫调节作用。它的产物,如分泌组和外泌体,也被研究过,它们对再生过程有很多好处。这种新的治疗方法具有显著的潜力,可以加速神经重建后的神经愈合,并有可能延缓靶器官的退行性过程,使其在神经再生完成后对新的信号做出反应。本文就干细胞及其产物在神经修复中的应用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regenerative Medicine: A New Horizon in Peripheral Nerve Injury and Repair.

A peripheral nerve injury is a great burden for the patient and a challenge for the clinician. In a complete injury (axonotmesis or neurotmesis), the slow nature of nerve regeneration after repair or reconstruction hardly catches up to the target organ's degeneration rate, leading to a poor prognosis. The current advance in regenerative medicine has shown the potency of stem cells and their products for healing many human body structures, including the nerve. A comprehensive literature search was conducted using an internet-based search engine for current advances in regenerative medicine to augment peripheral nerve repair or reconstruction. Stem cells can differentiate into nerve cells and have paracrine and immunomodulatory effects. Its products, such as the secretome and exosome, have also been studied, and they have many benefits for the regeneration process. This novel treatment possesses significant potential to accelerate nerve healing after nerve reconstruction and potentially postpone the degenerative process in the target organ, allowing it to respond to the new signal once nerve regeneration is complete. The aim of this article is to summarized the application of stem cells and its products for nerve healing.

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来源期刊
Orthopedic Reviews
Orthopedic Reviews ORTHOPEDICS-
CiteScore
2.70
自引率
4.80%
发文量
122
审稿时长
10 weeks
期刊介绍: Orthopedic Reviews is an Open Access, online-only, peer-reviewed journal that considers articles concerned with any aspect of orthopedics, as well as diagnosis and treatment, trauma, surgical procedures, arthroscopy, sports medicine, rehabilitation, pediatric and geriatric orthopedics. All bone-related molecular and cell biology, genetics, pathophysiology and epidemiology papers are also welcome. The journal publishes original articles, brief reports, reviews and case reports of general interest.
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