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IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-04-02 DOI:10.1038/s41372-025-02285-2

Chiara Autilio, Lhousseine Touqui, Silvia Foligno, Raquel Arroyo, Paul S Kingma, Alejandro A Alonso, Jesus Perez-Gil, Daniele De Luca

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引用次数: 0

摘要

目标：研究低体温对表面活性蛋白、抗炎和促纤维化介质的影响研究低温对表面活性物质蛋白、抗炎和促纤维化介质的影响设计：前瞻性、实用性研究，纳入无肺损伤的窒息新生儿。在低体温之前、期间和之后采集的支气管肺泡灌洗液中测量表面活性蛋白（SP）、会厌细胞分泌蛋白（CC-10）、肿瘤生长因子-β1（TGF-β1）、人成纤维细胞生长因子-2（hFGF）和抗炎白细胞介素（IL）：对 12 名新生儿进行了研究。SP-A、-B、-C、-D 和 CC-10 水平在低体温前后和期间相似。低体温期间 hFGF 水平下降（低体温前 = 92 [52-193.6]，低体温期间 = 19.4 [0-42.6]，低体温后 = 31.8 [0-83] 纳克/毫升，p = 0.026），低体温前的水平明显高于低体温期间和低体温后的水平（p = 0.025）：结论：在无任何肺部疾病的降温新生儿中，低体温与较低的 hFGF 相关，但与表面活性蛋白或抗炎分子的任何变化无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.

Objectives: To study the effect of hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators DESIGN: Prospective, pragmatic study enrolling asphyxiated neonates without lung injury. Surfactant proteins (SP), Club cell secretory protein (CC-10), tumor growth factor-β1 (TGF-β1), human fibroblast growth factor-2 (hFGF) and anti-inflammatory interleukins (IL) were measured in broncho-alveolar lavage fluids obtained before, during and after hypothermia.

Results: Twelve neonates were studied. SP-A, -B, -C, -D and CC-10 levels were similar before, during and after hypothermia. IL-10, IL-13, IL-14 were inconsistently detected only in five out of twelve patients and not in all timepoints; TGF-β1 was always undetectable. hFGF decreased during hypothermia (pre = 92 [52-193.6], during = 19.4 [0-42.6], post = 31.8 [0-83] ng/mL, p = 0.026) with levels before hypothermia being significantly higher than those obtained during and after the treatment (post hoc p = 0.025).

Conclusions: In cooled neonates without any lung disorder, hypothermia is associated with lower hFGF but not with any changes in surfactant proteins or anti-inflammatory molecules.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.