转移hpv癌负担：从宫颈癌到口咽癌。

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2025-04-02 DOI:10.1186/s13027-025-00649-z

Connor R Volpi, Anna R Giuliano, Edith Morais, Marisa Felsher

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引用次数: 0

摘要

目的：本研究旨在探讨女性宫颈癌（CC）发病率下降和男性口咽癌（OPC）发病率上升的对比趋势。方法：该分析考察了公共卫生举措，包括CC筛查计划和HPV疫苗接种工作，以及OPC不断变化的流行病学。结果：CC发病率下降归因于改进筛查和HPV疫苗接种。相反，男性的OPC率正在上升，这主要与HPV感染和缺乏成熟的筛查计划有关。数据表明，在一些国家，男性的外阴癌负担高于女性的外阴癌负担。结论：应对不断上升的OPC趋势需要采取多方面的方法，包括性别中立的HPV疫苗接种，开发OPC筛查方法，以及提高公众意识。持续努力预防hpv相关癌症对于缓解这些相反趋势至关重要。

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Shifting HPV-cancer burden: from cervical cancer to oropharyngeal cancer.

Purpose: This study aims to explore the contrasting trends of decreasing cervical cancer (CC) rates among women and increasing oropharyngeal cancer (OPC) rates among men.

Methods: The analysis examines public health initiatives, including CC screening programs and HPV vaccination efforts, alongside the changing epidemiology of OPC.

Results: Declines in CC incidence are attributed to improved screening and HPV vaccination. Conversely, OPC rates are rising among men, linked primarily to HPV infection and lack of established screening programs. Data indicate a higher OPC burden in men compared to CC in women in several countries.

Conclusion: Addressing the rising OPC trend requires a multifaceted approach, including gender-neutral HPV vaccination, the development of OPC screening methods, and increased public awareness. Sustained efforts in HPV-related cancer prevention are crucial to mitigate these opposing trends.

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.