Christina Stevens, Elizabeth Kawecki-Wright, Avery Rowlison de Ortiz, Andrea Thomson, Savannah Aker, Erin Perry, Emily Haupt, Alejandra Mondino, Masataka Enomoto, Margaret E Gruen, B Duncan X Lascelles
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引用次数: 0
摘要
背景：加速度计可用于测量体力活动，是评估伴侣动物骨关节炎（OA）疼痛影响的有效客观测量方法。然而，除 OA 疼痛外，还有其他一些因素会影响狗的体力活动，而人们对这些因素的影响却知之甚少。功能线性建模（FLM）是一种分析和可视化高频纵向数据（如体力活动）的方法，可用于评估各种因素对活动模式的影响。本研究旨在使用FLM来研究各种因素对患有OA疼痛的狗的体育锻炼模式的影响：方法：为 99 只有放射学和临床证据表明患有 OA 的客户饲养的狗安装了项圈式活动监测器（Actigraph GT3X）。在 7 天内每分钟记录一次平均矢量幅度，然后取平均值，为每只狗创建 24 小时、每分钟的活动曲线。收集了人口统计学信息、狗主人填写的 OA 临床计量工具（利物浦犬骨关节炎和犬简易疼痛量表）以及兽医检查结果（关节疼痛、肌肉萎缩）。使用 FLM 和定制的 R 软件包对数据进行分析，以评估各因素对 24 小时体力活动模式的影响：结果：在 24 小时活动高峰期，后肢 OA 疼痛、年龄较高、临床计量仪器评分较高、关节疼痛较高、身体状况评分较高和肌肉萎缩程度较高的狗的活动量都有所减少。然而，只有年龄、后肢关节疼痛和后肢肌肉萎缩对体力活动有统计学意义：有多种因素会影响患有 OA 疼痛的狗的活动模式。了解哪些因素以及这些因素如何影响患有 OA 疼痛的狗的活动模式，将有助于在临床疼痛研究中将体力活动作为一种客观的结果测量方法。
Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain.
Background: Accelerometry can be used to measure physical activity and is a validated objective measure for evaluating the impact of osteoarthritis (OA) pain in companion animals. However, several factors other than OA pain can affect physical activity in dogs, and relatively little is understood about their influence. Functional linear modeling (FLM) is an approach for analyzing and visualizing high-frequency longitudinal data such as physical activity and can be used to assess the influence of factors on activity patterns. This study aimed to use FLM to investigate the effect of various factors on physical activity patterns in a cohort of dogs with OA pain.
Methods: Ninety-nine client-owned dogs with radiographic and clinical evidence of OA were fitted with a collar-based activity monitor (Actigraph GT3X). Average vector magnitudes were recorded once per minute over 7 days and averaged to create 24-h, per-minute activity profiles for each dog. Demographic information, owner completed OA Clinical Metrology Instruments (Liverpool Osteoarthritis in Dogs and Canine Brief Pain Inventory), and veterinary examination findings (joint pain, muscle atrophy) were collected. Data were analyzed using FLM and a custom R package to evaluate the effect of each factor on 24-h patterns of physical activity.
Results: At times of peak activity within a 24-h period, dogs with hindlimb OA pain, higher age, higher Clinical Metrology Instrument scores, higher joint pain, greater Body Condition Score and greater muscle atrophy all had decreased activity profiles. However, only age, hindlimb joint pain, and hindlimb muscle atrophy had statistically significant effects on physical activity.
Conclusions and clinical relevance: Several factors influence activity patterns in dogs with OA pain. Understanding what and how factors influence patterns in dogs with OA pain will help refine the usage of physical activity as an objective outcome measure in clinical pain studies.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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