- Book学术

发布求助

文献互助智能选刊最新文献

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-03-11 eCollection Date: 2025-04-01 DOI:10.1093/ofid/ofaf131

Aftab Ullah, Muhammad Shabil, Saud A Abdulsamad, Asif Jan, Abdulghani A Naeem, Haseen Ullah, Mudassir Khattak, Zakiullah

{"title":"Prevalence of the Antibiotic Resistance of Salmonella typhi and Salmonella paratyphi in Pakistan: A Systematic Review and Meta-analysis.","authors":"Aftab Ullah, Muhammad Shabil, Saud A Abdulsamad, Asif Jan, Abdulghani A Naeem, Haseen Ullah, Mudassir Khattak, Zakiullah","doi":"10.1093/ofid/ofaf131","DOIUrl":null,"url":null,"abstract":"Background: Antibiotic resistance to Salmonella is a significant threat to public health globally, particularly in low- and middle-income countries such as Pakistan. This study reviews the existing literature to determine the pooled prevalence of antibiotic resistance among Salmonella typhi and Salmonella paratyphi strains across Pakistan in the past decade, including the emergence of extended-spectrum β-lactamase.Methods: Six databases were searched for studies published from January 2014 to December 2024. Studies were screened for relevance, and data were extracted on antibiotic susceptibility among human S typhi and S paratyphi isolates. Their quality was assessed per the Joanna Briggs Institute checklist. A random effects model was employed by R statistical software (version 4.4) to calculate the pooled resistance rates.Results: Thirty-one studies met the inclusion criteria after full-text screening. The analysis revealed significant resistance rates to commonly used antibiotics for S typhi, including nalidixic acid (92%; 95% CI, 88%-95%), ampicillin (80%; 95% CI, 66%-89%), ciprofloxacin (64%; 95% CI, 48%-77%), azithromycin (7%; 95% CI, 3%-16%), and meropenem (2%; 95% CI, 1%-3%), with notable variations across cities, and for S paratyphi, such as nalidixic acid (91%; 95% CI, 82%-96%), ampicillin (34%; 95% CI, 21%-50%), ciprofloxacin (51%; 95% CI, 25%-77%), azithromycin (4%; 95% CI, 1%-12%), and meropenem (2%; 95% CI, 1%-5%). In S typhi, 29% and 25% of patients had multidrug resistance (95% CI, 21%-41%) and extensive drug resistance (95% CI, 12%-44%), respectively; corresponding rates for S paratyphi were 9% (95% CI, 2%-28%) and 2% (95% CI, 1%-7%).Conclusions: The findings revealed the alarming prevalence of antibiotic-resistant Salmonella in Pakistan and the need for updated treatment guidelines. Public health strategies must focus on improving antibiotic use and developing alternative treatment options to mitigate the rising threat of resistant Salmonella strains. Continued research, policy intervention, and national and international cooperation are essential to safeguard public health and ensure effective management of enteric fever.","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 4","pages":"ofaf131"},"PeriodicalIF":3.8000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962718/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofaf131","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：沙门氏菌的抗生素耐药性是对全球公共卫生的重大威胁，尤其是在巴基斯坦等中低收入国家。本研究回顾了现有文献，以确定过去十年巴基斯坦各地伤寒沙门氏菌和副伤寒沙门氏菌菌株的抗生素耐药性总流行率，包括扩展谱β-内酰胺酶的出现情况：检索了六个数据库中 2014 年 1 月至 2024 年 12 月期间发表的研究。筛选了相关研究，并提取了人类伤寒杆菌和副伤寒杆菌分离株的抗生素敏感性数据。研究质量按照乔安娜-布里格斯研究所（Joanna Briggs Institute）的核对表进行评估。R 统计软件（4.4 版）采用随机效应模型计算汇总耐药率：经过全文筛选，31 项研究符合纳入标准。分析显示，伤寒杆菌对常用抗生素的耐药率很高，包括萘啶酸（92%；95% CI，88%-95%）、氨苄西林（80%；95% CI，66%-89%）、环丙沙星（64%；95% CI，48%-77%）、阿奇霉素（7%；95% CI，3%-16%）和美罗培南（2%；对于副伤寒杆菌，如纳利昔酸（91%；95% CI，82%-96%）、氨苄西林（34%；95% CI，21%-50%）、环丙沙星（51%；95% CI，25%-77%）、阿奇霉素（4%；95% CI，1%-12%）和美罗培南（2%；95% CI，1%-5%）。在伤寒杆菌中，分别有29%和25%的患者具有多重耐药性（95% CI，21%-41%）和广泛耐药性（95% CI，12%-44%）；副伤寒杆菌的相应比率分别为9%（95% CI，2%-28%）和2%（95% CI，1%-7%）：研究结果表明，巴基斯坦耐抗生素沙门氏菌的流行程度令人担忧，需要更新治疗指南。公共卫生战略必须侧重于改善抗生素的使用和开发替代治疗方案，以减轻耐药沙门氏菌株不断上升的威胁。持续的研究、政策干预以及国家和国际合作对于保障公众健康和确保有效管理肠道热病至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Prevalence of the Antibiotic Resistance of Salmonella typhi and Salmonella paratyphi in Pakistan: A Systematic Review and Meta-analysis.

Background: Antibiotic resistance to Salmonella is a significant threat to public health globally, particularly in low- and middle-income countries such as Pakistan. This study reviews the existing literature to determine the pooled prevalence of antibiotic resistance among Salmonella typhi and Salmonella paratyphi strains across Pakistan in the past decade, including the emergence of extended-spectrum β-lactamase.

Methods: Six databases were searched for studies published from January 2014 to December 2024. Studies were screened for relevance, and data were extracted on antibiotic susceptibility among human S typhi and S paratyphi isolates. Their quality was assessed per the Joanna Briggs Institute checklist. A random effects model was employed by R statistical software (version 4.4) to calculate the pooled resistance rates.

Results: Thirty-one studies met the inclusion criteria after full-text screening. The analysis revealed significant resistance rates to commonly used antibiotics for S typhi, including nalidixic acid (92%; 95% CI, 88%-95%), ampicillin (80%; 95% CI, 66%-89%), ciprofloxacin (64%; 95% CI, 48%-77%), azithromycin (7%; 95% CI, 3%-16%), and meropenem (2%; 95% CI, 1%-3%), with notable variations across cities, and for S paratyphi, such as nalidixic acid (91%; 95% CI, 82%-96%), ampicillin (34%; 95% CI, 21%-50%), ciprofloxacin (51%; 95% CI, 25%-77%), azithromycin (4%; 95% CI, 1%-12%), and meropenem (2%; 95% CI, 1%-5%). In S typhi, 29% and 25% of patients had multidrug resistance (95% CI, 21%-41%) and extensive drug resistance (95% CI, 12%-44%), respectively; corresponding rates for S paratyphi were 9% (95% CI, 2%-28%) and 2% (95% CI, 1%-7%).

Conclusions: The findings revealed the alarming prevalence of antibiotic-resistant Salmonella in Pakistan and the need for updated treatment guidelines. Public health strategies must focus on improving antibiotic use and developing alternative treatment options to mitigate the rising threat of resistant Salmonella strains. Continued research, policy intervention, and national and international cooperation are essential to safeguard public health and ensure effective management of enteric fever.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.