青光眼患者视功能改善与视网膜微循环增强相关性强。

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1537741
Ting Wang, Qiying Ling, Boyu Shen, Xu Jia
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引用次数: 0

摘要

摘要:本研究旨在探讨青光眼患者有效眼压(IOP)降低后视网膜血管密度(VD)的变化,并探讨视网膜血管密度与视觉功能和视神经结构的关系。方法:纳入诊断为原发性开角型青光眼(POAG)和慢性原发性闭角型青光眼(CPACG)的患者。我们在治疗前、治疗后1周、1个月、3个月和6个月测量了乳头周围和黄斑VD、视网膜神经纤维层(RNFL)厚度、中央凹无血管区(FAZ)和视野(VF)参数。数据分析采用方差分析和Pearson相关分析。结果:共纳入20例患者。乳头周围VD在1周时观察到上、鼻段显著改善,1个月时观察到上、下、颞段改善,3个月时观察到上、下、颞段改善,6个月时观察到上、鼻、颞段持续改善。黄斑VD在1周时在所有部位均有恢复,主要是在1个月时在上副中央,3个月时在上、下副中央和下窝周围,6个月时下副中央和窝周围进一步改善。在前3个月内,FAZ区域明显缩小。平均偏差(MD)值在1周、3个月和6个月时增加。值得注意的是,上、下段乳头周围VD的变化与MD值有很强的相关性,而鼻段和颞段的相关性较弱。相反,IOP变化与MD的相关性较弱。讨论:有效降低IOP有利于乳头周围微循环和黄斑微循环的恢复,从而改善视功能,提示在降低IOP的同时积极改善视网膜微循环可能有助于慢性青光眼患者部分恢复视功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The strong correlation between visual function improvement and retinal microcirculation enhancement in glaucoma.

Introduction: This study aimed to investigate the alterations in retinal vessel density (VD) among glaucomatous patients following effective intraocular pressure (IOP) reduction and to explore the relationship between retinal VD, visual function, and optic nerve structure.

Methods: Participants diagnosed with primary open-angle glaucoma (POAG) and chronic primary angle-closure glaucoma (CPACG) were included. We measured peripapillary and macular VD, retinal nerve fiber layer (RNFL) thickness, foveal avascular zone (FAZ), and visual field (VF) parameters before treatment, and at 1 week, 1 month, 3 months, and 6 months post-treatment. The data were analyzed using ANOVA and Pearson correlation analysis.

Results: A total of 20 patients were included. Significant improvements in peripapillary VD were observed in the superior and nasal sectors at 1 week, superior and temporal sectors at 1 month, and in the superior, inferior, and temporal sectors at 3 months, with sustained improvements in the superior, nasal, and temporal sectors at 6 months. Recovery of macular VD was noted across all sectors at 1 week, predominantly in the superior parafovea at 1 month, and in the superior, inferior parafovea, and inferior perifovea by 3 months, with further improvement in the inferior parafovea and perifovea at 6 months. The FAZ area significantly narrowed within the first 3 months. The mean deviation (MD) value demonstrated an increase at 1 week, 3 months, and 6 months. Notably, changes in peripapillary VD in the superior and inferior sectors exhibited a strong correlation with MD values, while correlations in the nasal and temporal sectors were moderate. Conversely, the correlation between IOP changes and MD was weak.

Discussion: Effective IOP reduction was beneficial for the recovery of both peripapillary and macular microcirculation, leading to improvements in visual function, suggesting that actively improving retinal microcirculation while reducing IOP may contribute to partial recovery of visual function for patients with chronic glaucoma.

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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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