外用咪喹莫特和原位外阴黑色素瘤：一个有希望的治疗方法？

IF 2.6 3区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Gynecology & Obstetrics Pub Date : 2025-04-03 DOI:10.1002/ijgo.70087

Francesca Pepe, Flavia Silvestri, Eleonora Petra Preti, Anna Daniela Iacobone, Gianluigi Radici, Sabina Vaccari, Paola Queirolo, Giulio Tosti

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引用次数: 0

摘要

目的：外阴黑色素瘤是一种罕见的癌症类型，主要影响绝经后妇女。对于外阴黑色素瘤的治疗尚无既定的方案。从文献中推断的皮肤黑色素瘤数据来看，手术切除仍然是可切除疾病的最佳选择。咪喹莫特是一种局部免疫调节剂，已被用于外阴原位黑色素瘤的选定病例。方法和结果:我们报告两例原位外阴的黑色素瘤治疗局部咪喹莫特5%,作为一线治疗或辅助治疗,显示一个完整的局部治疗的临床反应。结论：考察了咪喹莫特治疗外阴原位黑色素瘤的利弊。

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Topical imiquimod and in situ vulvar melanoma: A promising therapy?

Objectives: Vulvar melanoma is a rare type of cancer that affects mainly postmenopausal women. There are no established protocols for the treatment of vulvar melanoma. From data extrapolated from the literature on cutaneous melanoma, surgical excision remains the best option for the resectable disease. Imiquimod, a topical immunomodulator, has been used in selected cases of in situ vulvar melanoma.

Methods and results: We reported two cases of in situ vulvar melanoma treated with topical imiquimod 5%, either as first-line therapy or adjuvant treatment, that showed a complete clinical response to topical treatment.

Conclusion: Imiquimod's beneficial and adverse effects in in situ vulvar melanoma treatment are examined.

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来源期刊

International Journal of Gynecology & Obstetrics 医学-妇产科学

CiteScore

5.80

自引率

2.60%

发文量

493

审稿时长

3-6 weeks

期刊介绍： The International Journal of Gynecology & Obstetrics publishes articles on all aspects of basic and clinical research in the fields of obstetrics and gynecology and related subjects, with emphasis on matters of worldwide interest.