病例报告:痤疮丙酸杆菌阳性的纹身结节病伴上皮样细胞肉芽肿。

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1552114
Yuiko Masuda, Hiroko Okabayashi, Kimitaka Akaike, Shohei Hamada, Aiko Masunaga, Hidenori Ichiyasu, Kenichi Ohashi, Takuro Sakagami
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引用次数: 0

摘要

文身结节病的特点是文身部位出现肉芽肿反应,是文身结节病的典型全身症状。在此,我们报告一个被诊断为纹身结节病的病人。病例报告:一名28岁男性,两处纹身部位皮下结节,双侧肺门和纵隔淋巴结肿大,双肺上叶多发微结节,血清血管紧张素转换酶和可溶性白介素-2受体水平升高,高钙血症和肾功能障碍。皮下结节的皮肤活检显示上皮样细胞肉芽肿。虽然周期性酸-希夫染色、Grocott甲基胺银染色和抗酸染色为阴性,但上皮样细胞肉芽肿内的痤疮丙酸杆菌抗体染色为阳性。值得注意的是,所有病变自发消退,全身表现也有所改善,无需药物治疗。结论:纹身结节病的发病机制尚不清楚,尽管对纹身色素的免疫反应已被怀疑。然而,有一种理论认为痤疮杆菌是结节病的病原体。在本病例中,在上皮样细胞肉芽肿内检测到痤疮杆菌,表明该细菌可能在纹身结节病的病因学中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Case Report: Tattoo sarcoidosis with epithelioid cell granuloma positive for Propionibacterium acnes.

Introduction: Tattoo sarcoidosis is characterized by a granulomatous reaction localized to the tattoo site and typical systemic symptoms of sarcoidosis. Herein, we report the case of a patient diagnosed with tattoo sarcoidosis.

Case report: A 28-year-old man presented with subcutaneous nodules at two tattoo sites, bilateral hilar and mediastinal lymphadenopathy, multiple micronodules predominantly in the upper lobes of both lungs, elevated serum angiotensin-converting enzyme and soluble interleukin-2 receptor levels, hypercalcemia, and renal dysfunction. Skin biopsy of a subcutaneous nodule revealed epithelioid cell granulomas. Although periodic acid-Schiff, Grocott methenamine silver, and acid-fast staining showed negative results, antibody staining for Propionibacterium acnes within the epithelioid cell granuloma was positive. Remarkably, all lesions spontaneously resolved, and the systemic manifestations also improved without medical treatment.

Conclusion: The pathogenesis of tattoo sarcoidosis remains unknown, although an immune response to tattoo pigments has been suspected. However, there is a theory that P. acnes is the causative agent of sarcoidosis. In the present case, the detection of P. acnes within the epithelioid cell granuloma suggests that the bacterium may play a role in the etiology of tattoo sarcoidosis.

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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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