透明质酸四糖通过被动扩散渗入皮肤，促进皮肤健康。

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c23-00909

Yutaka Takagi, Madoka Kage

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引用次数: 0

摘要

透明质酸（HA）具有多种药理活性，是化妆品和药品中常用的原料。然而，由于其分子量大，透明质酸渗透皮肤的能力很差，大部分停留在皮肤表面。因此，局部应用的透明质酸不能指望在皮肤中发挥生物学作用。然而，我们已经证实HA四糖（HA4）是HA的最小单位，通过被动扩散渗透到皮肤中并影响表皮代谢。局部治疗HA4可挽救长期UVA照射引起的表皮损伤。此外，在细胞培养研究中观察到HA4维持皮肤健康的各种生物学功能。本文综述了HA4的皮肤通透性及其对皮肤健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hyaluronan Tetrasaccharides Penetrate into the Skin by Passive Diffusion and Contribute to Skin Health.

Hyaluronan (HA) is a commonly used material in cosmetics and pharmaceuticals because of its various pharmacological activities. However, because of its large molecular weight, HA penetrates the skin very poorly and most of it remains on the skin surface. Thus, topically applied HA could not be expected to function biologically in the skin. However, we have confirmed that HA tetrasaccharides (HA4), which is the smallest unit of HA, penetrate into the skin by passive diffusion and affect epidermal metabolism. Topical treatment of HA4 rescues the epidermal damage caused by long-term UVA irradiation. Furthermore, various biological functions of HA4 to maintain healthy skin was observed in cell culture studies. This review describes the skin permeability of HA4 and how it contributes to healthy skin.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.