动脉期CT放射组学无创预测胰腺实体性假乳头状肿瘤Ki-67增殖指数。

IF 2.2 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jun Liu, Huanhua Wu, Dabin Ren, Hao Huang, Xinyue Chen, Liqiu Liu, Yongtao Wang, Guoyu Wang
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引用次数: 0

摘要

背景:本研究旨在利用从动脉期螺旋CT图像中提取的放射组学特征,预测胰腺实性假乳头状肿瘤(pSPN)患者术前Ki-67增殖水平。方法:回顾性分析2015年6月至2023年6月间经病理证实的92例pSPN患者(宁波医疗中心丽丽丽医院64例,台州中心医院28例)。Ki-67阳性bb0.3 %被认为是高的。使用PyRadiomics提取放射组学特征,来自训练队列(n = 64)和验证队列(n = 28)的患者。构建放射组学特征,计算CT放射组学评分(CTscore)。采用深度学习模型进行预测,并提前停止以防止过拟合。结果:通过LASSO回归交叉验证筛选出7个关键放射组学特征。深度学习模型在人口统计学和CTscore方面显示出更高的准确性,形态学和CTscore等关键特征对预测准确性有显著贡献。表现最好的模型,包括GBM和深度学习算法,在训练队列中取得了很高的预测性能,AUC高达0.946。结论:我们开发了一个强大的基于深度学习的放射组学模型,使用动脉期CT图像预测pSPN患者的Ki-67水平,将ct评分和形态学作为关键预测指标。这种非侵入性方法在指导个性化术前治疗策略方面具有潜在的效用。临床试验号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Arterial phase CT radiomics for non-invasive prediction of Ki-67 proliferation index in pancreatic solid pseudopapillary neoplasms

Arterial phase CT radiomics for non-invasive prediction of Ki-67 proliferation index in pancreatic solid pseudopapillary neoplasms

Arterial phase CT radiomics for non-invasive prediction of Ki-67 proliferation index in pancreatic solid pseudopapillary neoplasms

Background

This study aimed to preoperatively predict Ki-67 proliferation levels in patients with pancreatic solid pseudopapillary neoplasm (pSPN) using radiomics features extracted from arterial phase helical CT images.

Methods

We retrospectively analyzed 92 patients (Ningbo Medical Center Lihuili Hospital: n = 64, Taizhou Central Hospital: n = 28) with pathologically confirmed pSPN from June 2015 to June 2023. Ki-67 positivity > 3% was considered high. Radiomics features were extracted using PyRadiomics, with patients from training cohort (n = 64) and validation cohort (n = 28). A radiomics signature was constructed, and a CT radiomics score (CTscore) was calculated. Deep learning models were employed for prediction, with early stopping to prevent overfitting.

Results

Seven key radiomics features were selected via LASSO regression with cross-validation. The deep learning model demonstrated improved accuracy with demographics and CTscore, with key features such as Morphology and CTscore contributing significantly to predictive accuracy. The best-performing models, including GBM and deep learning algorithms, achieved high predictive performance with an AUC of up to 0.946 in the training cohort.

Conclusions

We developed a robust deep learning-based radiomics model using arterial phase CT images to predict Ki-67 levels in pSPN patients, identifying CTscore and Morphology as key predictors. This non-invasive approach has potential utility in guiding personalized preoperative treatment strategies.

Clinical trial number

Not applicable.

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来源期刊
Abdominal Radiology
Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.20
自引率
8.30%
发文量
334
期刊介绍: Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits
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