帕金森病中vcam1介导的多巴胺能神经元功能调节。

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

BMB Reports Pub Date : 2025-05-01

Mihee Oh, Sunha Lee, Eunhye Kim, Yewon Jang, Baek-Soo Han

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引用次数: 0

摘要

帕金森病（PD）是第二常见的神经退行性疾病，其特征是多巴胺能神经元变性、纹状体多巴胺缺乏和细胞内α-突触核蛋白聚集体的积累。在这项研究中，我们采用诱导多能干细胞（iPSC）技术从PD患者和健康对照的体细胞中产生多巴胺能神经元。我们的研究结果表明，患者来源的神经元表现出血管细胞粘附分子1 （VCAM1）的表达升高，这与突触可塑性改变、线粒体功能障碍以及Rac1和FAK2信号通路受损有关。这些发现表明VCAM1在PD发病机制中起关键作用，可能作为潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

VCAM1-mediated regulation of dopaminergic neuron function in Parkinson's disease.

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by the degeneration of dopaminergic neurons, striatal dopamine deficiency, and the accumulation of intracellular α-synuclein aggregates. This study employed induced pluripotent stem cell (iPSC) technology to generate dopaminergic neurons from somatic cells of both PD patients and healthy controls. The results demonstrate that patient-derived neurons show elevated expression of vascular cell adhesion molecule 1 (VCAM1), which correlates with altered synaptic plasticity, mitochondrial dysfunction, and impaired Rac1 and FAK2 signaling. These findings suggest that VCAM1 plays a pivotal role in PD pathogenesis, and may serve as a potential therapeutic target. [BMB Reports 2025; 58(5): 217-223].

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来源期刊

BMB Reports 生物-生化与分子生物学

CiteScore

5.10

自引率

7.90%

发文量

141

审稿时长

1 months

期刊介绍： The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.