{"title":"硼酸配合物的战略性n迁移:远程C-C键构建的新平台。","authors":"Yi-Ming Chen, Xue Li, Zhi-Gang Xu","doi":"10.1007/s11030-025-11169-8","DOIUrl":null,"url":null,"abstract":"<p><p>Organoboron compounds play a pivotal role in diverse scientific disciplines, including chemistry, materials science, energy research, and medicinal chemistry. In recent years, research efforts have predominantly focused on 1,2-metallate migrations of tetracoordinate boronate complexes, while remote migrations, particularly 1,n-metallate migrations (n > 2), remain challenging due to their inherent complexity. This comprehensive review systematically examines seminal contributions to the field of 1,n-metallate migration reactions (n > 2). Our critical analysis reveals that progress in this domain has been fundamentally driven by the strategic design and synthesis of novel tetracoordinate boron complexes, with a notable evolution from conventional O-B coordination motifs to more sophisticated C-B-bonded architectures. Recent methodological advancements have further expanded the structural diversity and mechanistic understanding of these transformations. Although the number of reported cases remains limited and the research landscape is somewhat fragmented, the existing systems underscore the significance of these migration reactions, drawing considerable attention to this area and inspiring further exploration.</p>","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Strategic 1,n-migration of boronate complexes: a novel platform for remote C-C bond construction.\",\"authors\":\"Yi-Ming Chen, Xue Li, Zhi-Gang Xu\",\"doi\":\"10.1007/s11030-025-11169-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Organoboron compounds play a pivotal role in diverse scientific disciplines, including chemistry, materials science, energy research, and medicinal chemistry. In recent years, research efforts have predominantly focused on 1,2-metallate migrations of tetracoordinate boronate complexes, while remote migrations, particularly 1,n-metallate migrations (n > 2), remain challenging due to their inherent complexity. This comprehensive review systematically examines seminal contributions to the field of 1,n-metallate migration reactions (n > 2). Our critical analysis reveals that progress in this domain has been fundamentally driven by the strategic design and synthesis of novel tetracoordinate boron complexes, with a notable evolution from conventional O-B coordination motifs to more sophisticated C-B-bonded architectures. Recent methodological advancements have further expanded the structural diversity and mechanistic understanding of these transformations. Although the number of reported cases remains limited and the research landscape is somewhat fragmented, the existing systems underscore the significance of these migration reactions, drawing considerable attention to this area and inspiring further exploration.</p>\",\"PeriodicalId\":708,\"journal\":{\"name\":\"Molecular Diversity\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Diversity\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s11030-025-11169-8\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Diversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11030-025-11169-8","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Strategic 1,n-migration of boronate complexes: a novel platform for remote C-C bond construction.
Organoboron compounds play a pivotal role in diverse scientific disciplines, including chemistry, materials science, energy research, and medicinal chemistry. In recent years, research efforts have predominantly focused on 1,2-metallate migrations of tetracoordinate boronate complexes, while remote migrations, particularly 1,n-metallate migrations (n > 2), remain challenging due to their inherent complexity. This comprehensive review systematically examines seminal contributions to the field of 1,n-metallate migration reactions (n > 2). Our critical analysis reveals that progress in this domain has been fundamentally driven by the strategic design and synthesis of novel tetracoordinate boron complexes, with a notable evolution from conventional O-B coordination motifs to more sophisticated C-B-bonded architectures. Recent methodological advancements have further expanded the structural diversity and mechanistic understanding of these transformations. Although the number of reported cases remains limited and the research landscape is somewhat fragmented, the existing systems underscore the significance of these migration reactions, drawing considerable attention to this area and inspiring further exploration.
期刊介绍:
Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including:
combinatorial chemistry and parallel synthesis;
small molecule libraries;
microwave synthesis;
flow synthesis;
fluorous synthesis;
diversity oriented synthesis (DOS);
nanoreactors;
click chemistry;
multiplex technologies;
fragment- and ligand-based design;
structure/function/SAR;
computational chemistry and molecular design;
chemoinformatics;
screening techniques and screening interfaces;
analytical and purification methods;
robotics, automation and miniaturization;
targeted libraries;
display libraries;
peptides and peptoids;
proteins;
oligonucleotides;
carbohydrates;
natural diversity;
new methods of library formulation and deconvolution;
directed evolution, origin of life and recombination;
search techniques, landscapes, random chemistry and more;