临床医生迟发性量表（CTI）的验证性研究

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-06-01 Epub Date: 2025-03-29 DOI:10.1016/j.parkreldis.2025.107812

Richard M. Trosch , Alicia C. Shillington , Cynthia L. Comella , Stanley N. Caroff , William G. Ondo , Brandon J. LaChappelle , Qing Harshaw , Robert A. Hauser , Christoph U. Correll , Joseph H. Friedman

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引用次数: 0

摘要

目前临床评定的迟发性运动障碍（TD）症状量表没有涉及扩展的临床体征和功能影响。临床医生迟发性量表（CTI）是由运动障碍专家和精神科医生设计的一种新开发的记录工具。它由6个解剖域组成，产生联合运动振幅/频率严重程度评分（CSS）和一个功能性疼痛。本研究检验了CTI的有效性。方法对患者进行录像评估，并对同一患者进行CTI评分和不自主运动异常量表（AIMS）评分。通过斯皮尔曼rho， CTI CSS和AIMS运动障碍评分之间的一致性来确定结构效度。探索性分析检验了CTI功能评分、AIMS功能题9和10与CTI CSS之间的相关性。我们对比AIMS第9题和第10题检查了AIMS运动障碍评分。结果对70例患者进行了评估。平均（SD）年龄：59（12）岁；51%（73%）为女性。CSS和AIMS运动障碍评分高度相关：0.770 （95% CI 0.653, 0.851）。CTI功能评分也与AIMS功能题9:0.626 （95% CI 0.458, 0.750）和题10:0.771 （95% CI 0.655, 0.852）高度相关。CSS与CTI功能评分没有很好的相关性：0.285 （95% CI .0536, .487）。AIMS运动障碍得分也与问题9,0.299 （95% CI 0.069, 0.499）和10,395 （95% CI 0.176, 0.576）呈弱相关。结论scti纳入了现象学的最新认识，并证明了评估TD运动严重程度的有效性。与临床经验一致，运动严重程度与功能影响无关。

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A validation study of the Clinician's Tardive Inventory (CTI)

Current clinician-rated tardive dyskinesia (TD) symptom scales do not address expanding clinical signs and functional impacts. The Clinician's Tardive Inventory (CTI) is a newly developed instrument documenting designed by movement disorder specialists and psychiatrists. It is comprised of 6 anatomic domains generating a combined movement amplitude/frequency severity score (CSS), and a functional sore. This study tested the validity of the CTI.

Methods

Videotaped patient assessments and vignettes were rated with the CTI and Abnormal Involuntary Movement Scale (AIMS) administered on the same patient. Construct validity was determined by agreement between the CTI CSS and AIMS dyskinesia score via a Spearman rho. Exploratory analyses examined correlations between the CTI Functional Score, AIMS functional questions 9 and 10, and the CTI CSS. We examined the AIMS dyskinesia score versus AIMS questions 9 and 10.

Results

Seventy patients were assessed. Mean (SD) age: 59 (12) years; 51 % (73 %) were female. CSS and AIMS dyskinesia scores were highly correlated: .770 (95 % CI .653, .851). CTI Functional Score was also highly correlated with the AIMS functional questions 9: .626 (95 % CI .458, .750) and question 10: .771 (95 % CI .655, .852). CSS was not well correlated with the CTI Functional score: .285 (95 % CI .0536, .487). AIMS dyskinesia score was also weakly correlated with questions 9: .299 (95 % CI .069, .499), and 10: .395 (95 % CI .176, .576.).

Conclusions

CTI incorporates updated understanding of phenomenology and demonstrates validity in assessing TD movement severity. Consistent with clinical experience, movement severity does not correlate with functional impacts.

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.