组蛋白赖氨酸去甲基化酶的20年：从发现到临床及以后

IF 42.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-04-03 DOI:10.1016/j.cell.2025.02.023

Zach H. Gray, Madison A. Honer, Pooja Ghatalia, Yang Shi, Johnathan R. Whetstine

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引用次数: 0

摘要

20年前，组蛋白赖氨酸去甲基酶（kdm）被发现。自从它们被发现以来，人们对它们的研究越来越多，并证明它们在物种、发育和疾病中都很重要。在了解它们(1)酶学，(2)作为生物复合物的关键组成部分的作用，(3)在正常细胞过程和功能中的作用，(4)在病理条件下的意义，以及(5)治疗潜力方面取得了相当大的进展。这篇综述涵盖了与KDM领域相关的这些关键关系，并意识到许多实验室在这一领域做出了贡献。目前的知识加上未来的见解将塑造我们对细胞功能、发育、疾病发生和进展的理解，这将允许识别新的生物标志物，并在未来几年为kdm相关疾病开发最佳治疗方案。

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20 years of histone lysine demethylases: From discovery to the clinic and beyond

Twenty years ago, histone lysine demethylases (KDMs) were discovered. Since their discovery, they have been increasingly studied and shown to be important across species, development, and diseases. Considerable advances have been made toward understanding their (1) enzymology, (2) role as critical components of biological complexes, (3) role in normal cellular processes and functions, (4) implications in pathological conditions, and (5) therapeutic potential. This Review covers these key relationships related to the KDM field with the awareness that numerous laboratories have contributed to this field. The current knowledge coupled with future insights will shape our understanding about cell function, development, and disease onset and progression, which will allow for novel biomarkers to be identified and for optimal therapeutic options to be developed for KDM-related diseases in the years ahead.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.