工程心脏组织贴片：心脏再生医学的里程碑

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-04-03 DOI:10.1016/j.stem.2025.02.012

Alain van Mil, Jasmijn Janssen, Eva van Rooij

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引用次数: 0

摘要

研究人员已经证明，干细胞来源的心脏肌肉贴片可以安全地使衰竭的心脏再肌肉化发表在《自然》杂志上的这项研究表明，在灵长类动物模型和人类患者身上成功地实现了心脏贴片的长期整合，没有任何副作用。这一突破标志着晚期心力衰竭的再生治疗迈出了重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Engineered heart tissue patches: A milestone in cardiac regenerative medicine

Researchers have demonstrated that a stem cell-derived heart muscle patch can safely remuscularize failing hearts.¹ Published in Nature, the study shows successful long-term cardiac integration of a patch in a primate model and a human patient with no adverse effects. This breakthrough marks a major step toward regenerative therapies for advanced heart failure.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.