Yakup Alsancak, Ahmet Taha Sahin, Oznur Keskin, Selman Parlak
{"title":"内皮PAS结构域蛋白1和胃饥饿素对系统性红斑狼疮患者心脏影响的研究。","authors":"Yakup Alsancak, Ahmet Taha Sahin, Oznur Keskin, Selman Parlak","doi":"10.1590/1806-9282.20241412","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Systemic lupus erythematosus is a chronic autoimmune disease with significant cardiac manifestations, including right ventricular dysfunction and pulmonary hypertension. This study aims to explore the relationship between endothelial PAS domain-containing protein 1 and ghrelin levels with right ventricular function in patients with systemic lupus erythematosus and assess their potential as biomarkers for cardiac involvement.</p><p><strong>Methods: </strong>A prospective study was conducted involving 34 patients with systemic lupus erythematosus and 35 healthy controls. Echocardiographic parameters were recorded. Serum levels of endothelial PAS domain-containing protein 1 and ghrelin were measured using enzyme-linked immunosorbent assay. Statistical analyses included comparisons between groups and correlations between biomarkers and echocardiographic parameters.</p><p><strong>Results: </strong>Patients with systemic lupus erythematosus had significantly higher levels of endothelial PAS domain-containing protein 1 and ghrelin compared with healthy controls (p<0.001). Endothelial PAS domain-containing protein 1 showed a moderate positive correlation with right ventricular systolic motion (p=0.007). Patients with systemic lupus erythematosus and a higher disease activity had elevated endothelial PAS domain-containing protein 1 levels, particularly those with positive antiphospholipid antibodies (p<0.001). No significant correlation was found between ghrelin levels and right ventricular function. Receiver operating characteristic curve analysis identified cutoff values for endothelial PAS domain-containing protein 1 (≥1.871) and ghrelin (≥360.50) with moderate sensitivity and specificity for predicting systemic lupus erythematosus.</p><p><strong>Conclusion: </strong>This study suggests that endothelial PAS domain-containing protein 1 and ghrelin may play important roles in the pathophysiology of right ventricular dysfunction in systemic lupus erythematosus.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 2","pages":"e20241412"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964316/pdf/","citationCount":"0","resultStr":"{\"title\":\"Investigation of the cardiac impacts of endothelial PAS domain-containing protein 1 and ghrelin in patients with systemic lupus erythematosus.\",\"authors\":\"Yakup Alsancak, Ahmet Taha Sahin, Oznur Keskin, Selman Parlak\",\"doi\":\"10.1590/1806-9282.20241412\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Systemic lupus erythematosus is a chronic autoimmune disease with significant cardiac manifestations, including right ventricular dysfunction and pulmonary hypertension. This study aims to explore the relationship between endothelial PAS domain-containing protein 1 and ghrelin levels with right ventricular function in patients with systemic lupus erythematosus and assess their potential as biomarkers for cardiac involvement.</p><p><strong>Methods: </strong>A prospective study was conducted involving 34 patients with systemic lupus erythematosus and 35 healthy controls. Echocardiographic parameters were recorded. Serum levels of endothelial PAS domain-containing protein 1 and ghrelin were measured using enzyme-linked immunosorbent assay. Statistical analyses included comparisons between groups and correlations between biomarkers and echocardiographic parameters.</p><p><strong>Results: </strong>Patients with systemic lupus erythematosus had significantly higher levels of endothelial PAS domain-containing protein 1 and ghrelin compared with healthy controls (p<0.001). Endothelial PAS domain-containing protein 1 showed a moderate positive correlation with right ventricular systolic motion (p=0.007). Patients with systemic lupus erythematosus and a higher disease activity had elevated endothelial PAS domain-containing protein 1 levels, particularly those with positive antiphospholipid antibodies (p<0.001). No significant correlation was found between ghrelin levels and right ventricular function. Receiver operating characteristic curve analysis identified cutoff values for endothelial PAS domain-containing protein 1 (≥1.871) and ghrelin (≥360.50) with moderate sensitivity and specificity for predicting systemic lupus erythematosus.</p><p><strong>Conclusion: </strong>This study suggests that endothelial PAS domain-containing protein 1 and ghrelin may play important roles in the pathophysiology of right ventricular dysfunction in systemic lupus erythematosus.</p>\",\"PeriodicalId\":94194,\"journal\":{\"name\":\"Revista da Associacao Medica Brasileira (1992)\",\"volume\":\"71 2\",\"pages\":\"e20241412\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964316/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista da Associacao Medica Brasileira (1992)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/1806-9282.20241412\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Associacao Medica Brasileira (1992)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1806-9282.20241412","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Investigation of the cardiac impacts of endothelial PAS domain-containing protein 1 and ghrelin in patients with systemic lupus erythematosus.
Objective: Systemic lupus erythematosus is a chronic autoimmune disease with significant cardiac manifestations, including right ventricular dysfunction and pulmonary hypertension. This study aims to explore the relationship between endothelial PAS domain-containing protein 1 and ghrelin levels with right ventricular function in patients with systemic lupus erythematosus and assess their potential as biomarkers for cardiac involvement.
Methods: A prospective study was conducted involving 34 patients with systemic lupus erythematosus and 35 healthy controls. Echocardiographic parameters were recorded. Serum levels of endothelial PAS domain-containing protein 1 and ghrelin were measured using enzyme-linked immunosorbent assay. Statistical analyses included comparisons between groups and correlations between biomarkers and echocardiographic parameters.
Results: Patients with systemic lupus erythematosus had significantly higher levels of endothelial PAS domain-containing protein 1 and ghrelin compared with healthy controls (p<0.001). Endothelial PAS domain-containing protein 1 showed a moderate positive correlation with right ventricular systolic motion (p=0.007). Patients with systemic lupus erythematosus and a higher disease activity had elevated endothelial PAS domain-containing protein 1 levels, particularly those with positive antiphospholipid antibodies (p<0.001). No significant correlation was found between ghrelin levels and right ventricular function. Receiver operating characteristic curve analysis identified cutoff values for endothelial PAS domain-containing protein 1 (≥1.871) and ghrelin (≥360.50) with moderate sensitivity and specificity for predicting systemic lupus erythematosus.
Conclusion: This study suggests that endothelial PAS domain-containing protein 1 and ghrelin may play important roles in the pathophysiology of right ventricular dysfunction in systemic lupus erythematosus.
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