Justine M. Mucinski, David E. Kelley, Stephen J. Winters, Bret H. Goodpaster
{"title":"减肥对男性和女性睾酮、性激素结合球蛋白、肥胖和胰岛素敏感性的影响。","authors":"Justine M. Mucinski, David E. Kelley, Stephen J. Winters, Bret H. Goodpaster","doi":"10.1002/oby.24269","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Testosterone and glucose disposal (Rd) are positively associated in adult men, whereas the opposite is reported in women. Sex-specific relationships between testosterone or sex hormone-binding globulin (SHBG) and Rd in men and women with and without obesity and following weight loss were examined.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Adult men and women (<i>n</i> = 27/28; BMI = 20–41 kg/m<sup>2</sup>) underwent measurements of body composition, Rd, SHBG, and bioavailable (BioA) and total testosterone. Men and women (<i>n</i> = 17/15) with obesity completed a 16-week dietary weight-loss program with repeat testing.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>BioA testosterone was lower in men with obesity and was related to Rd positively in men and negatively in women (<i>p</i> < 0.05). Across participants, weight loss increased Rd and SHBG (<i>p</i> < 0.01). BioA testosterone was unchanged in men; however, individual changes were independently related to Rd (<i>p</i> = 0.031). In women, BioA testosterone declined (<i>p</i> < 0.009) but was not related to Rd.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>BioA testosterone was associated with Rd, positively in men and negatively in women. Weight loss reduced BioA testosterone in women; however, individual changes were associated with improved Rd in men. SHBG was a better correlate of improved Rd in women. Additional studies should identify mechanisms that drive sex differences and interventions that modify testosterone, reduce adiposity, and improve Rd across both sexes.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 5","pages":"962-973"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of weight loss on testosterone, sex hormone-binding globulin, adiposity, and insulin sensitivity in women and men\",\"authors\":\"Justine M. Mucinski, David E. Kelley, Stephen J. Winters, Bret H. Goodpaster\",\"doi\":\"10.1002/oby.24269\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Testosterone and glucose disposal (Rd) are positively associated in adult men, whereas the opposite is reported in women. Sex-specific relationships between testosterone or sex hormone-binding globulin (SHBG) and Rd in men and women with and without obesity and following weight loss were examined.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Adult men and women (<i>n</i> = 27/28; BMI = 20–41 kg/m<sup>2</sup>) underwent measurements of body composition, Rd, SHBG, and bioavailable (BioA) and total testosterone. Men and women (<i>n</i> = 17/15) with obesity completed a 16-week dietary weight-loss program with repeat testing.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>BioA testosterone was lower in men with obesity and was related to Rd positively in men and negatively in women (<i>p</i> < 0.05). Across participants, weight loss increased Rd and SHBG (<i>p</i> < 0.01). BioA testosterone was unchanged in men; however, individual changes were independently related to Rd (<i>p</i> = 0.031). In women, BioA testosterone declined (<i>p</i> < 0.009) but was not related to Rd.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>BioA testosterone was associated with Rd, positively in men and negatively in women. Weight loss reduced BioA testosterone in women; however, individual changes were associated with improved Rd in men. SHBG was a better correlate of improved Rd in women. Additional studies should identify mechanisms that drive sex differences and interventions that modify testosterone, reduce adiposity, and improve Rd across both sexes.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":\"33 5\",\"pages\":\"962-973\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24269\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24269","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Effects of weight loss on testosterone, sex hormone-binding globulin, adiposity, and insulin sensitivity in women and men
Objective
Testosterone and glucose disposal (Rd) are positively associated in adult men, whereas the opposite is reported in women. Sex-specific relationships between testosterone or sex hormone-binding globulin (SHBG) and Rd in men and women with and without obesity and following weight loss were examined.
Methods
Adult men and women (n = 27/28; BMI = 20–41 kg/m2) underwent measurements of body composition, Rd, SHBG, and bioavailable (BioA) and total testosterone. Men and women (n = 17/15) with obesity completed a 16-week dietary weight-loss program with repeat testing.
Results
BioA testosterone was lower in men with obesity and was related to Rd positively in men and negatively in women (p < 0.05). Across participants, weight loss increased Rd and SHBG (p < 0.01). BioA testosterone was unchanged in men; however, individual changes were independently related to Rd (p = 0.031). In women, BioA testosterone declined (p < 0.009) but was not related to Rd.
Conclusions
BioA testosterone was associated with Rd, positively in men and negatively in women. Weight loss reduced BioA testosterone in women; however, individual changes were associated with improved Rd in men. SHBG was a better correlate of improved Rd in women. Additional studies should identify mechanisms that drive sex differences and interventions that modify testosterone, reduce adiposity, and improve Rd across both sexes.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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