研究对羟基苯甲酸甲酯氧化应激对虹鳟鱼血液、肝脏和肾脏毒性的影响。

IF 1.5 3区 农林科学 Q2 VETERINARY SCIENCES
Mert Calisir, Gokhan Nur, Emrah Caylak
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引用次数: 0

摘要

对羟基苯甲酸酯的广泛使用导致其在水生环境中积累。本研究考察了对羟基苯甲酸甲酯对虹鳟鱼的影响,将96条鱼分为对照组和实验组(1毫克/升、5毫克/升和8毫克/升)。结果显示剂量依赖性体重减轻,肝体指标改变,血清尿素、尿酸和丙二醛(MDA)水平升高,谷胱甘肽过氧化物酶(GSH-Px)活性降低。组织病理学分析显示,治疗组肝脏和肾脏异常,包括肝细胞变性、胆管增生、肾小球萎缩、造血组织减少、黑素巨噬细胞中心增加、坏死和纤维化。贡献:这些发现强调了对羟基苯甲酸甲酯的毒性作用,强调需要更严格的法规和进一步的研究来保护水生生态系统,并了解其对水生生物的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating methylparaben's oxidative stress effects on rainbow trout blood, liver, and kidney toxicity.

The widespread use of parabens has led to their accumulation in aquatic environments. This study examined the effects of methylparaben on rainbow trout, dividing 96 fish into control and treatment groups (1 mg/L, 5 mg/L, and 8 mg/L). Results showed dose-dependent weight loss, altered hepatosomatic indices, increased serum urea, uric acid, and Malondialdehyde (MDA) levels, and decreased Glutathione Peroxidase (GSH-Px) activity. Histopathological analysis revealed liver and kidney abnormalities in treated groups, including hepatocyte degeneration, proliferation in the bile duct, glomerular atrophy, reduced haematopoietic tissue, increased melanomacrophage centres, necrosis and fibrosis.Contribution: These findings highlight methylparaben's toxic effects, emphasising the need for stricter regulations and further research to safeguard aquatic ecosystems and understand its impact on aquatic organisms.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
13
审稿时长
16 weeks
期刊介绍: The Onderstepoort Journal of Veterinary Research, is the official publication of the Onderstepoort Veterinary Institute. While it considers submissions from any geographic region, its focus is on Africa and the infectious and parasitic diseases and disease vectors that affect livestock and wildlife on the continent.
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