肩峰下反复注射帕瑞昔布与曲安奈德对大鼠正常肩袖模型影响的比较研究。

IF 1.9 2区 医学 Q2 ORTHOPEDICS
Clinics in Orthopedic Surgery Pub Date : 2025-04-01 Epub Date: 2025-01-02 DOI:10.4055/cios23417
Jong Pil Yoon, Dong Hyun Kim, Sung-Jin Park, Yoon Seong Choi, Hyun Joo Lee, Seok Won Chung, Kang-San Lee, Jeoung Wook Lee
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引用次数: 0

摘要

背景:本研究旨在探讨正常大鼠肩袖模型在肩峰下反复注射药物后的变化。方法:雄性Sprague-Dawley大鼠39只,随机分为1组(未注射,n = 3)、2组(帕瑞昔布,n = 18;6个子组,每组n = 3;0.5 mg/kg), 3(曲安奈德,n = 18;6个子组,每组n = 3;0.3毫克/公斤)。2、3组均给予肩峰下注射1 ~ 6次,每周1次,连用6周。冈上肌和冈下肌进行生物力学和组织学评价。采用肩峰下囊法检测前列腺素E2 (PEG2)水平。结果:在生物力学试验中,2组和3组反复注射后,载荷-失效和极限应力均降低,且3组仅在第6次注射时显著低于1组(p = 0.007和p = 0.008)。在Bonar评分上,在第5次和第6次注射时,3组间细胞度、基质物质和总分(细胞度分别为p = 0.028和p = 0.033,基质物质分别为p = 0.018和p = 0.006,总分分别为p = 0.029和p = 0.027)均有显著差异。第三次、第四次注射时三组冈下肌肌细胞横截面积差异有统计学意义(p = 0.031、p = 0.020)。三组患者第3、5、6次注射时肩峰下囊PEG2水平差异有统计学意义(p = 0.019、p = 0.004、p = 0.004)。结论:在大鼠正常肌腱套模型中,局部重复注射环氧化酶-2抑制剂对正常肌腱生物力学和组织学特性的负面影响小于曲安奈德。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparative Study on the Effects of Repeated Subacromial Injections of Parecoxib and Triamcinolone in a Rat Model of Normal Rotator Cuff.

Backgroud: This study aimed to investigate changes after repeated subacromial drug injections in a rat model of normal rotator cuff.

Methods: Thirty-nine male Sprague-Dawley rats were divided into groups 1 (no injection, n = 3), 2 (parecoxib, n = 18; 6 subgroups, n = 3 each; 0.5 mg/kg), and 3 (triamcinolone, n = 18; 6 subgroups, n = 3 each; 0.3 mg/kg). Groups 2 and 3 received subacromial injections 1-6 times once weekly for 6 weeks. The supraspinatus and infraspinatus tendons and muscles were used for biomechanical and histological evaluation. The subacromial bursa was used to analyze the prostaglandin E2 (PEG2) level.

Results: In the biomechanical test, load-to-failure and ultimate stress decreased in groups 2 and 3 with repeated injections and the values were significantly lower in group 3 than in group 1 only at the sixth injection (p = 0.007 and p = 0.008, respectively). On the Bonar score, the cellularity, ground substance, and total score were significantly different among the 3 groups at the fifth and sixth injections (cellularity: p = 0.028 and p = 0.033, ground substance: p = 0.018 and p = 0.006, and total score: p = 0.029 and p = 0.027, respectively). The myocyte cross-sectional area of the infraspinatus muscle showed a significant difference among the 3 groups at the third and fourth injections (p = 0.031 and p = 0.020, respectively). The PEG2 level in the subacromial bursa was significantly different among the 3 groups at the third, fifth, and sixth injections (p = 0.019, p = 0.004, and p = 0.004, respectively).

Conclusions: In the rat model of normal rotator cuff, repeated local injections of the cyclooxygenase-2 inhibitor showed fewer negative effects on the biomechanical and histological properties of the normal tendon than triamcinolone.

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来源期刊
CiteScore
3.50
自引率
4.00%
发文量
85
审稿时长
36 weeks
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