在不同认知正常的老年人人群中，嗜睡测量与主观认知衰退症状之间的关系。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-04-01 DOI:10.1177/13872877251331237

Anthony Q Briggs, Carolina Boza-Calvo, Mark A Bernard, Henry Rusinek, Rebecca A Betensky, Arjun V Masurkar

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引用次数: 0

摘要

主观认知能力下降（SCD）与临床前阿尔茨海默病（AD）相关。睡眠不佳也是认知能力下降的危险因素，但与SCD的关系尚不清楚。我们对148名认知正常的老年人进行了一项回顾性横断面研究，这些老年人接受了SCD(认知变化指数；CCI)，嗜睡(爱普沃斯嗜睡量表；ESS)、抑郁(老年抑郁量表；GDS)和淀粉样蛋白/tau PET。在调整GDS、淀粉样蛋白/tau负担和种族后，ESS评分与总CCI评分、遗忘性和非遗忘性CCI评分相关。这支持了未来关于嗜睡如何影响SCD结果的纵向研究。

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The association between measures of sleepiness and subjective cognitive decline symptoms in a diverse population of cognitively normal older adults.

Subjective cognitive decline (SCD) is associated with preclinical Alzheimer's disease (AD). Suboptimal sleep is also a risk factor for cognitive decline, but with unclear relationship to SCD. We conducted a retrospective cross-sectional study in a biracial research cohort of 148 cognitively normal older adults who underwent quantification of SCD (Cognitive Change Index; CCI), sleepiness (Epworth Sleepiness Scale; ESS), depression (Geriatric Depression Scale; GDS), and amyloid/tau PET. ESS score was associated with total, amnestic, and non-amnestic CCI scores, after adjustment for GDS, amyloid/tau burden, and race. This supports future longitudinal work on how sleepiness impacts SCD outcomes.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.