IF 12.5 2区 医学 Q1 SURGERY
Wei Ding, Jiaao Sun, Shiyan Song, Yuying Cui, Feng Chen, Qihang Yuan, Wei Shang
{"title":"Junction Plakoglobin - A Dual-Role Player in Cancer Biology.","authors":"Wei Ding, Jiaao Sun, Shiyan Song, Yuying Cui, Feng Chen, Qihang Yuan, Wei Shang","doi":"10.1097/JS9.0000000000002365","DOIUrl":null,"url":null,"abstract":"<p><p>Junction plakoglobin (JUP) is a critical cell adhesion molecule implicated in mediating cell-cell adhesion. Cancer, characterized by the loss of normal cellular regulation, results in unchecked proliferation and the breakdown of cell-cell junctions, facilitating malignant cell invasion into surrounding tissues. Recent studies have highlighted the involvement of JUP in the transduction of various intercellular signaling pathways, underscoring its significant role in tumor initiation, progression, and prognosis. In contrast to its homolog β-catenin, the interplay between JUP and cancer remains underexplored. To clarify JUP's role and underlying mechanisms in cancer progression, this review examines recent advancements, focusing on JUP's regulation of key cancer-related signaling pathways, such as Wnt/β-catenin, p53, and cadherin-mediated pathways. The review also investigates JUP's relevance across various cancer types, including those of the reproductive, digestive, and urinary systems. Mechanistically, JUP exhibits context-dependent actions in different cancers, demonstrating dual roles in tumorigenesis. Lastly, the potential of JUP as a target for early diagnosis, effective treatment, and prognostic prediction in cancer is evaluated. In conclusion, targeting JUP offers a promising avenue for cancer therapy, providing valuable insights for future research.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/JS9.0000000000002365","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

摘要

接合素(JUP)是一种重要的细胞粘附分子,与介导细胞-细胞粘附有关。癌症的特点是失去正常的细胞调控,导致细胞无节制地增殖,细胞-细胞连接被破坏,从而促进恶性细胞侵入周围组织。最近的研究突出表明,JUP 参与了各种细胞间信号通路的转导,强调了它在肿瘤的发生、发展和预后中的重要作用。与其同源物β-catenin相比,JUP与癌症之间的相互作用仍未得到充分探索。为了阐明 JUP 在癌症进展中的作用和内在机制,本综述研究了最近的进展,重点关注 JUP 对关键癌症相关信号通路的调控,如 Wnt/β-catenin、p53 和干细胞介导的通路。综述还研究了 JUP 与各种癌症类型的相关性,包括生殖系统、消化系统和泌尿系统癌症。从机理上讲,JUP 在不同癌症中表现出与环境相关的作用,显示了其在肿瘤发生过程中的双重作用。最后,还评估了 JUP 作为癌症早期诊断、有效治疗和预后预测靶点的潜力。总之,以 JUP 为靶点为癌症治疗提供了一条前景广阔的途径,为未来的研究提供了宝贵的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Junction Plakoglobin - A Dual-Role Player in Cancer Biology.

Junction plakoglobin (JUP) is a critical cell adhesion molecule implicated in mediating cell-cell adhesion. Cancer, characterized by the loss of normal cellular regulation, results in unchecked proliferation and the breakdown of cell-cell junctions, facilitating malignant cell invasion into surrounding tissues. Recent studies have highlighted the involvement of JUP in the transduction of various intercellular signaling pathways, underscoring its significant role in tumor initiation, progression, and prognosis. In contrast to its homolog β-catenin, the interplay between JUP and cancer remains underexplored. To clarify JUP's role and underlying mechanisms in cancer progression, this review examines recent advancements, focusing on JUP's regulation of key cancer-related signaling pathways, such as Wnt/β-catenin, p53, and cadherin-mediated pathways. The review also investigates JUP's relevance across various cancer types, including those of the reproductive, digestive, and urinary systems. Mechanistically, JUP exhibits context-dependent actions in different cancers, demonstrating dual roles in tumorigenesis. Lastly, the potential of JUP as a target for early diagnosis, effective treatment, and prognostic prediction in cancer is evaluated. In conclusion, targeting JUP offers a promising avenue for cancer therapy, providing valuable insights for future research.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信