Abby J. deSteiguer, Laurel Raffington, Aditi Sabhlok, Peter Tanksley, Elliot M. Tucker-Drob, K. Paige Harden
{"title":"儿童和青少年衰老和认知相关甲基化谱评分在两波中的稳定性。","authors":"Abby J. deSteiguer, Laurel Raffington, Aditi Sabhlok, Peter Tanksley, Elliot M. Tucker-Drob, K. Paige Harden","doi":"10.1111/cdev.14239","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (<i>M</i><sub>lag</sub> between waves = 2.41 years) from <i>N</i> = 407 participants (<i>M</i><sub>age</sub> = 12.05 years, 51% female, 60% White), test–retest correlations were estimated for four salivary MPSs related to aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), and cognitive function (Epigenetic-<i>g</i>). MPSs varied in longitudinal stability (test–retest <i>r</i>s = 0.38 to 0.76). MPSs did not differ in children exposed to the COVID-19 pandemic, but race-ethnic and sex differences were apparent. Further research is necessary to understand which environmental perturbations impact DNA-methylation trajectories and when children are most sensitive to those impacts.</p>\n </div>","PeriodicalId":10109,"journal":{"name":"Child development","volume":"96 3","pages":"1189-1206"},"PeriodicalIF":3.9000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stability of Aging- and Cognition-Related Methylation Profile Scores Across Two Waves in Children and Adolescents\",\"authors\":\"Abby J. deSteiguer, Laurel Raffington, Aditi Sabhlok, Peter Tanksley, Elliot M. Tucker-Drob, K. Paige Harden\",\"doi\":\"10.1111/cdev.14239\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (<i>M</i><sub>lag</sub> between waves = 2.41 years) from <i>N</i> = 407 participants (<i>M</i><sub>age</sub> = 12.05 years, 51% female, 60% White), test–retest correlations were estimated for four salivary MPSs related to aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), and cognitive function (Epigenetic-<i>g</i>). MPSs varied in longitudinal stability (test–retest <i>r</i>s = 0.38 to 0.76). MPSs did not differ in children exposed to the COVID-19 pandemic, but race-ethnic and sex differences were apparent. Further research is necessary to understand which environmental perturbations impact DNA-methylation trajectories and when children are most sensitive to those impacts.</p>\\n </div>\",\"PeriodicalId\":10109,\"journal\":{\"name\":\"Child development\",\"volume\":\"96 3\",\"pages\":\"1189-1206\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Child development\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cdev.14239\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, DEVELOPMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Child development","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cdev.14239","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, DEVELOPMENTAL","Score":null,"Total":0}
Stability of Aging- and Cognition-Related Methylation Profile Scores Across Two Waves in Children and Adolescents
DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (Mlag between waves = 2.41 years) from N = 407 participants (Mage = 12.05 years, 51% female, 60% White), test–retest correlations were estimated for four salivary MPSs related to aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), and cognitive function (Epigenetic-g). MPSs varied in longitudinal stability (test–retest rs = 0.38 to 0.76). MPSs did not differ in children exposed to the COVID-19 pandemic, but race-ethnic and sex differences were apparent. Further research is necessary to understand which environmental perturbations impact DNA-methylation trajectories and when children are most sensitive to those impacts.
期刊介绍：
As the flagship journal of the Society for Research in Child Development (SRCD), Child Development has published articles, essays, reviews, and tutorials on various topics in the field of child development since 1930. Spanning many disciplines, the journal provides the latest research, not only for researchers and theoreticians, but also for child psychiatrists, clinical psychologists, psychiatric social workers, specialists in early childhood education, educational psychologists, special education teachers, and other researchers. In addition to six issues per year of Child Development, subscribers to the journal also receive a full subscription to Child Development Perspectives and Monographs of the Society for Research in Child Development.
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