S9B家族的微生物二肽基肽酶作为宿主-微生物同工酶

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-04-02 DOI:10.1126/sciadv.ads5721

Mashael R. Aljumaah, Jeffery Roach, Yunan Hu, John Gunstad, M. Andrea Azcarate-Peril

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引用次数: 0

摘要

自21世纪初以来，人二肽基肽酶4 （hDPP-4）一直是代谢性疾病，特别是糖尿病的药理学靶点。作为一种普遍存在于原核生物和真核生物中的酶，hDPP-4在宿主体内平衡和疾病进展中起着至关重要的作用。虽然许多研究已经探索了hDPP-4的特性，但对肠道微生物来源的DPP-4 （mDPP-4）的研究仍然有限。本文讨论了mDPP-4的意义及其对健康的影响，分析了mDPP-4的晶体结构，并将其与人类相比较。我们研究了hDPP-4抑制剂如何影响肠道微生物组组成和mDPP-4活性。此外，本综述结合了目前关于DPP-4底物特异性和mDPP-4潜在通路的讨论，强调迫切需要进一步研究mDPP-4在健康中的作用，并提高DPP-4抑制剂治疗的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes

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Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes

Human dipeptidyl peptidase 4 (hDPP-4) has been a pharmacological target for metabolic diseases, particularly diabetes, since the early 2000s. As a ubiquitous enzyme found in both prokaryotic and eukaryotic organisms, hDPP-4 plays crucial roles in host homeostasis and disease progression. While many studies have explored hDPP-4’s properties, research on gut microbially derived DPP-4 (mDPP-4) remains limited. This review discusses the significance of mDPP-4 and its health implications, analyzing crystal structures of mDPP-4 in comparison to human counterparts. We examine how hDPP-4 inhibitors could influence gut microbiome composition and mDPP-4 activity. Additionally, this review connects ongoing discussions regarding DPP-4 substrate specificity and potential access routes for mDPP-4, emphasizing the urgent need for further research on mDPP-4’s role in health and improve the precision of DPP-4 inhibitor therapies.

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.